Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy.

Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy.

Spinal muscular atrophy (SMA) is a genetic disorder caused by a deletion of the survival motor neuron 1 gene leading to motor neuron loss, muscle atrophy, paralysis, and death. We show here that induced pluripotent stem cell (iPSC) lines generated from two Type I SMA subjects-one produced with lenti...

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Bibliographic Details
Main Authors: Dhruv Sareen, Allison D Ebert, Brittany M Heins, Jered V McGivern, Loren Ornelas, Clive N Svendsen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3378532?pdf=render

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