HIV, hepatitis B, and hepatitis C in Zambia
Objectives : Epidemiologic data of HIV and viral hepatitis coinfection are needed in sub-Saharan Africa to guide health policy for hepatitis screening and optimized antiretroviral therapy (ART). Materials and Methods: We screened 323 HIV-infected, ART-eligible adults for hepatitis B surface antigen...
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Wolters Kluwer Medknow Publications
2011-01-01
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doaj-03c00570779747c8a7a31480ec3df1572020-11-24T22:43:18ZengWolters Kluwer Medknow PublicationsJournal of Global Infectious Diseases0974-777X2011-01-013326927410.4103/0974-777X.83534HIV, hepatitis B, and hepatitis C in ZambiaKenneth C KapembwaJason D GoldmanShabir LakhiYolan BandaKasonde BowaSten H VermundJoseph MulengaDavid ChamaBenjamin H ChiObjectives : Epidemiologic data of HIV and viral hepatitis coinfection are needed in sub-Saharan Africa to guide health policy for hepatitis screening and optimized antiretroviral therapy (ART). Materials and Methods: We screened 323 HIV-infected, ART-eligible adults for hepatitis B surface antigen (HBsAg) and hepatitis C antibody (HCV Ab) at a tertiary hospital in Lusaka, Zambia. We collected basic demographic, medical, and laboratory data to determine predictors for coinfection. Results: Of 323 enrolled patients, 32 (9.9%; 95% CI=6.7-13.2%) were HBsAg positive, while 4 (1.2%; 95% CI=0.03-2.4%) were HCV Ab positive. Patients with hepatitis B coinfection were more likely to be <40 years (84.4% vs. 61.4%; P=0.01) when compared to those who were not coinfected. Patients with active hepatitis B were more likely to have mild to moderately elevated AST/ALT (40-199 IU/L, 15.8% vs. 5.4%; P=0.003). Highly elevated liver enzymes (>200 IU/L) was uncommon and did not differ between the two groups (3.4% vs. 2.3%; P=0.5). We were unable to determine predictors of hepatitis C infection due to the low prevalence of disease. Conclusions: HIV and hepatitis B coinfection was common among patients initiating ART at this tertiary care facility. Routine screening for hepatitis B should be considered for HIV-infected persons in southern Africa.http://www.jgid.org/article.asp?issn=0974-777X;year=2011;volume=3;issue=3;spage=269;epage=274;aulast=KapembwaAfricaHepatitis BHepatitis CHIVPrevalenceZambia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kenneth C Kapembwa Jason D Goldman Shabir Lakhi Yolan Banda Kasonde Bowa Sten H Vermund Joseph Mulenga David Chama Benjamin H Chi |
spellingShingle |
Kenneth C Kapembwa Jason D Goldman Shabir Lakhi Yolan Banda Kasonde Bowa Sten H Vermund Joseph Mulenga David Chama Benjamin H Chi HIV, hepatitis B, and hepatitis C in Zambia Journal of Global Infectious Diseases Africa Hepatitis B Hepatitis C HIV Prevalence Zambia |
author_facet |
Kenneth C Kapembwa Jason D Goldman Shabir Lakhi Yolan Banda Kasonde Bowa Sten H Vermund Joseph Mulenga David Chama Benjamin H Chi |
author_sort |
Kenneth C Kapembwa |
title |
HIV, hepatitis B, and hepatitis C in Zambia |
title_short |
HIV, hepatitis B, and hepatitis C in Zambia |
title_full |
HIV, hepatitis B, and hepatitis C in Zambia |
title_fullStr |
HIV, hepatitis B, and hepatitis C in Zambia |
title_full_unstemmed |
HIV, hepatitis B, and hepatitis C in Zambia |
title_sort |
hiv, hepatitis b, and hepatitis c in zambia |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Global Infectious Diseases |
issn |
0974-777X |
publishDate |
2011-01-01 |
description |
Objectives : Epidemiologic data of HIV and viral hepatitis coinfection are needed in sub-Saharan Africa to guide health policy for hepatitis screening and optimized antiretroviral therapy (ART). Materials and Methods: We screened 323 HIV-infected, ART-eligible adults for hepatitis B surface antigen (HBsAg) and hepatitis C antibody (HCV Ab) at a tertiary hospital in Lusaka, Zambia. We collected basic demographic, medical, and laboratory data to determine predictors for coinfection. Results: Of 323 enrolled patients, 32 (9.9%; 95% CI=6.7-13.2%) were HBsAg positive, while 4 (1.2%; 95% CI=0.03-2.4%) were HCV Ab positive. Patients with hepatitis B coinfection were more likely to be <40 years (84.4% vs. 61.4%; P=0.01) when compared to those who were not coinfected. Patients with active hepatitis B were more likely to have mild to moderately elevated AST/ALT (40-199 IU/L, 15.8% vs. 5.4%; P=0.003). Highly elevated liver enzymes (>200 IU/L) was uncommon and did not differ between the two groups (3.4% vs. 2.3%; P=0.5). We were unable to determine predictors of hepatitis C infection due to the low prevalence of disease. Conclusions: HIV and hepatitis B coinfection was common among patients initiating ART at this tertiary care facility. Routine screening for hepatitis B should be considered for HIV-infected persons in southern Africa. |
topic |
Africa Hepatitis B Hepatitis C HIV Prevalence Zambia |
url |
http://www.jgid.org/article.asp?issn=0974-777X;year=2011;volume=3;issue=3;spage=269;epage=274;aulast=Kapembwa |
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