Circular RNAs and RNase L in PKR activation and virus infection
Abstract Circular RNAs (circRNAs) from back-splicing have been found in every cell and tissue. By binding to miRNAs and proteins or even by encoding small proteins, circRNAs are now emerging as important regulators in modulating transcription, RNA splicing and interference. The highlighted discovery...
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2019-05-01
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| Series: | Cell & Bioscience |
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| Online Access: | http://link.springer.com/article/10.1186/s13578-019-0307-x |
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doaj-03c92dcd799a4079b3c0908de34b2b252020-11-25T03:08:26ZengBMCCell & Bioscience2045-37012019-05-01911310.1186/s13578-019-0307-xCircular RNAs and RNase L in PKR activation and virus infectionZhi-Ming Zheng0Tumor Virus RNA Biology Section, RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, NIHAbstract Circular RNAs (circRNAs) from back-splicing have been found in every cell and tissue. By binding to miRNAs and proteins or even by encoding small proteins, circRNAs are now emerging as important regulators in modulating transcription, RNA splicing and interference. The highlighted discovery reports an important role of circRNAs in antiviral innate immunity by binding PKR as PKR inhibitors. Rapid degradation of circRNAs by activated RNase L from virus infection or poly I:C stimulation is required to free PKR for its activation. Systemic lupus erythematosus patients remark with circRNA reduction and aberrant PKR activation.http://link.springer.com/article/10.1186/s13578-019-0307-xCircular RNAPKRInnate immunityRNase LSystemic lupus erythematosus |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Zhi-Ming Zheng |
| spellingShingle |
Zhi-Ming Zheng Circular RNAs and RNase L in PKR activation and virus infection Cell & Bioscience Circular RNA PKR Innate immunity RNase L Systemic lupus erythematosus |
| author_facet |
Zhi-Ming Zheng |
| author_sort |
Zhi-Ming Zheng |
| title |
Circular RNAs and RNase L in PKR activation and virus infection |
| title_short |
Circular RNAs and RNase L in PKR activation and virus infection |
| title_full |
Circular RNAs and RNase L in PKR activation and virus infection |
| title_fullStr |
Circular RNAs and RNase L in PKR activation and virus infection |
| title_full_unstemmed |
Circular RNAs and RNase L in PKR activation and virus infection |
| title_sort |
circular rnas and rnase l in pkr activation and virus infection |
| publisher |
BMC |
| series |
Cell & Bioscience |
| issn |
2045-3701 |
| publishDate |
2019-05-01 |
| description |
Abstract Circular RNAs (circRNAs) from back-splicing have been found in every cell and tissue. By binding to miRNAs and proteins or even by encoding small proteins, circRNAs are now emerging as important regulators in modulating transcription, RNA splicing and interference. The highlighted discovery reports an important role of circRNAs in antiviral innate immunity by binding PKR as PKR inhibitors. Rapid degradation of circRNAs by activated RNase L from virus infection or poly I:C stimulation is required to free PKR for its activation. Systemic lupus erythematosus patients remark with circRNA reduction and aberrant PKR activation. |
| topic |
Circular RNA PKR Innate immunity RNase L Systemic lupus erythematosus |
| url |
http://link.springer.com/article/10.1186/s13578-019-0307-x |
| work_keys_str_mv |
AT zhimingzheng circularrnasandrnaselinpkractivationandvirusinfection |
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1724666393688801280 |