Antimicrobial resistance of pathogens causing community-acquired urinary tract infections in Russia: results of the multicenter study “DARMIS-2018”
Objective. To study in vitro activity of antimicrobials against clinical isolates from patients with communityacquired urinary tract infections (UTIs) in different regions of Russia in 2017–2018. Materials and Methods. A total of 1052 Enterobacterales isolates collected in the Russian Federation...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | Russian |
Published: |
Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy
2019-10-01
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Series: | Клиническая микробиология и антимикробная химиотерапия |
Subjects: | |
Online Access: | https://cmac-journal.ru/publication/2019/2/cmac-2019-t21-n2-p134/cmac-2019-t21-n2-p134.pdf |
Summary: | Objective.
To study in vitro activity of antimicrobials against clinical isolates from patients with communityacquired urinary tract infections (UTIs) in different regions of Russia in 2017–2018.
Materials and Methods.
A total of 1052 Enterobacterales isolates collected in the Russian Federation as part of a multicenter, prospective, epidemiological study of the antimicrobial resistance of uropathogens causing community-acquired UTI in different subsets of patients (“DARMIS-2018”) were included in the analysis. Uropathogens were isolated from children and adults of both sexes in all age groups with acute (and recurrences of chronic) community-acquired UTIs, including pregnant women with asymptomatic bacteriuria in 32 centers of 24 cities of Russia in 2017–2018.
Results.
Enterobacterales comprised a total of 90.6% of all isolated bacterial pathogens (90.6% in the adult subset; 89.3% in the pregnant women subset and 93.8% in the children and adolescents subset). The most prevalent species were Escherichia coli (71.3% in the adult subset; 73.6% in the pregnant women subset; 79.7% in the children and adolescents subset) and Klebsiella pneumoniae (11.7% in the adult subset; 10.4% in the pregnant women subset; 7.8% in the children and adolescents subset). The highest activity against E. coli among the oral antimicrobials was demonstrated for fosfomycin (97.7% in the adult subset; 95.9% in the pregnant women subset; 99.0% in the children and adolescents subset) and nitrofurantoin (98.1% in adult subset; 100% in the pregnant women subset; 97.1% in the children and adolescents subset). Among the parenteral antimicrobials, meropenem and amikacin showed the highest activity (99.4% and 97.9% in the adult subset; 99.5% and 99.1% in the pregnant women subset; 100% and 97.1% in the children and adolescents subset, respectively). Ampicillin, amoxicillin/clavulanic acid and trimethoprim/sulfamethoxazole demonstrated the lowest in vitro activity against E. coli (less than 80% per each patient subset). The susceptibility of E. coli isolates to ciprofloxacin was 60.6% in the adult subset; 80.0% in the pregnant women subset and 80.4% in the children and adolescents subset. The rates of extended spectrum beta-lactamase production based on the results of phenotypic tests were 27.0% in the adult subset; 8.6% in the pregnant women subset and 23.5% in the children and adolescents subset.
Conclusions.
Results of this study indicated the increase in resistance of community-acquired isolates of Enterobacterales (particularly E. coli) to the most of antimicrobials in Russia. |
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ISSN: | 1684-4386 2686-9586 |