Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs

Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs

Oral administration is the most convenient route among various routes of drug delivery as it offers high patient compliance. However, the poor aqueous solubility and poor enzymatic/metabolic stability of drugs are major limitations in successful oral drug delivery. There are several approaches to im...

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Main Authors: Mayank Sharma, Rajesh Sharma, Dinesh Kumar Jain
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Scientifica
Online Access:http://dx.doi.org/10.1155/2016/8525679
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spelling doaj-03e195bc1bf34e49a73157b2f5adb9a22020-11-25T02:08:39ZengHindawi LimitedScientifica2090-908X2016-01-01201610.1155/2016/85256798525679Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive DrugsMayank Sharma0Rajesh Sharma1Dinesh Kumar Jain2School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore, IndiaSchool of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore, IndiaCollege of Pharmacy, IPS Academy, Indore, IndiaOral administration is the most convenient route among various routes of drug delivery as it offers high patient compliance. However, the poor aqueous solubility and poor enzymatic/metabolic stability of drugs are major limitations in successful oral drug delivery. There are several approaches to improve problems related to hydrophobic drugs. Among various approaches, nanotechnology based drug delivery system has potential to overcome the challenges associated with the oral route of administration. Novel drug delivery systems are available in many areas of medicine. The application of these systems in the treatment of hypertension continues to broaden. The present review focuses on various nanocarriers available in oral drug administration for improving solubility profile, dissolution, and consequently bioavailability of hydrophobic antihypertensive drugs.http://dx.doi.org/10.1155/2016/8525679
collection DOAJ
language English
format Article
sources DOAJ
author Mayank Sharma
Rajesh Sharma
Dinesh Kumar Jain
spellingShingle Mayank Sharma
Rajesh Sharma
Dinesh Kumar Jain
Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs
Scientifica
author_facet Mayank Sharma
Rajesh Sharma
Dinesh Kumar Jain
author_sort Mayank Sharma
title Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs
title_short Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs
title_full Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs
title_fullStr Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs
title_full_unstemmed Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs
title_sort nanotechnology based approaches for enhancing oral bioavailability of poorly water soluble antihypertensive drugs
publisher Hindawi Limited
series Scientifica
issn 2090-908X
publishDate 2016-01-01
description Oral administration is the most convenient route among various routes of drug delivery as it offers high patient compliance. However, the poor aqueous solubility and poor enzymatic/metabolic stability of drugs are major limitations in successful oral drug delivery. There are several approaches to improve problems related to hydrophobic drugs. Among various approaches, nanotechnology based drug delivery system has potential to overcome the challenges associated with the oral route of administration. Novel drug delivery systems are available in many areas of medicine. The application of these systems in the treatment of hypertension continues to broaden. The present review focuses on various nanocarriers available in oral drug administration for improving solubility profile, dissolution, and consequently bioavailability of hydrophobic antihypertensive drugs.
url http://dx.doi.org/10.1155/2016/8525679
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AT rajeshsharma nanotechnologybasedapproachesforenhancingoralbioavailabilityofpoorlywatersolubleantihypertensivedrugs
AT dineshkumarjain nanotechnologybasedapproachesforenhancingoralbioavailabilityofpoorlywatersolubleantihypertensivedrugs
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