Identification of predictors of drug sensitivity using patient-derived models of esophageal squamous cell carcinoma
Predicting the drug response of patients with cancer is crucial for implementing targeted therapy. Here, Su et al. make patient-derived cell lines and perform targeted sequencing and RNA-seq to identify CDKN2A/2B loss as a predictor of response to CDK4/6 inhibitors in esophageal squamous cell carcin...
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Bibliographic Details
Main Authors: |
Dan Su,
Dadong Zhang,
Jiaoyue Jin,
Lisha Ying,
Miao Han,
Kaiyan Chen,
Bin Li,
Junzhou Wu,
Zhenghua Xie,
Fanrong Zhang,
Yihui Lin,
Guoping Cheng,
Jing-Yu Li,
Minran Huang,
Jinchao Wang,
Kailai Wang,
Jianjun Zhang,
Fugen Li,
Lei Xiong,
Andrew Futreal,
Weimin Mao |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2019-11-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-019-12846-7
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