Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae)
The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg...
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Hindawi Limited
2021-01-01
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Series: | Evidence-Based Complementary and Alternative Medicine |
Online Access: | http://dx.doi.org/10.1155/2021/6622894 |
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doaj-03ed28da49194f4a88e55fea5875bc572021-02-22T00:01:51ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-42882021-01-01202110.1155/2021/6622894Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae)Orlando G. Elso0Maria Clavin1Natalia Hernandez2Tomás Sgarlata3Hernán Bach4César A. N. Catalan5Elena Aguilera6Guzman Alvarez7Valeria P. Sülsen8Universidad de Buenos AiresUniversidad de Buenos AiresUniversidad de Buenos AiresUniversidad de Buenos AiresUniversidad de Buenos AiresUniversidad Nacional de TucumánGrupo de Química Medicinal-Laboratorio de Química OrgánicaLaboratorio de Moléculas BioactivasUniversidad de Buenos AiresThe dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg/mL and 31 µg/mL, respectively. Fractionation of the dichloromethane extract led to the isolation of euparin, jaceidin, santhemoidin C, and eucannabinolide. The sesquiterpene lactones eucannabinolide and santhemoidin C were active on T. cruzi with IC50 values of 10 ± 2 µM (4.2 µg/mL) and 18 ± 3 µM (7.6 µg/mL), respectively. Euparin and santhemoidin C were the most active on L. infantum with IC50 values of 18 ± 4 µM (3.9 µg/mL) and 19 ± 4 µM (8.0 µg/mL), respectively. Eucannabinolide has also shown drug-like pharmacokinetic and toxicity properties.http://dx.doi.org/10.1155/2021/6622894 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Orlando G. Elso Maria Clavin Natalia Hernandez Tomás Sgarlata Hernán Bach César A. N. Catalan Elena Aguilera Guzman Alvarez Valeria P. Sülsen |
spellingShingle |
Orlando G. Elso Maria Clavin Natalia Hernandez Tomás Sgarlata Hernán Bach César A. N. Catalan Elena Aguilera Guzman Alvarez Valeria P. Sülsen Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae) Evidence-Based Complementary and Alternative Medicine |
author_facet |
Orlando G. Elso Maria Clavin Natalia Hernandez Tomás Sgarlata Hernán Bach César A. N. Catalan Elena Aguilera Guzman Alvarez Valeria P. Sülsen |
author_sort |
Orlando G. Elso |
title |
Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae) |
title_short |
Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae) |
title_full |
Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae) |
title_fullStr |
Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae) |
title_full_unstemmed |
Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae) |
title_sort |
antiprotozoal compounds from urolepis hecatantha (asteraceae) |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-4288 |
publishDate |
2021-01-01 |
description |
The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg/mL and 31 µg/mL, respectively. Fractionation of the dichloromethane extract led to the isolation of euparin, jaceidin, santhemoidin C, and eucannabinolide. The sesquiterpene lactones eucannabinolide and santhemoidin C were active on T. cruzi with IC50 values of 10 ± 2 µM (4.2 µg/mL) and 18 ± 3 µM (7.6 µg/mL), respectively. Euparin and santhemoidin C were the most active on L. infantum with IC50 values of 18 ± 4 µM (3.9 µg/mL) and 19 ± 4 µM (8.0 µg/mL), respectively. Eucannabinolide has also shown drug-like pharmacokinetic and toxicity properties. |
url |
http://dx.doi.org/10.1155/2021/6622894 |
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