Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations
Since the identification of succinate's receptor in 2004, studies supporting the involvement of succinate signaling through its receptor in various diseases have accumulated and most of these investigations have highlighted succinate's pro-inflammatory role. Taken with the fact that succin...
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doaj-03f112d051924f3491f50ad5c7efc78e2020-11-25T03:19:25ZengAcademya Publishing Co.Endocrinology and Metabolism2093-596X2093-59782020-03-01351364310.3803/EnM.2020.35.1.36Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular LocationsYuqi Guo0Sun Wook Cho1Deepak Saxena2Xin Li3Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, .USADepartment of Internal Medicine, Seoul National University Hospital, Seoul, .KoreaDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, .USADepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, .USASince the identification of succinate's receptor in 2004, studies supporting the involvement of succinate signaling through its receptor in various diseases have accumulated and most of these investigations have highlighted succinate's pro-inflammatory role. Taken with the fact that succinate is an intermediate metabolite in the center of mitochondrial activity, and considering its potential regulation of protein succinylation through succinyl-coenzyme A, a review on the overall multifaceted actions of succinate to discuss whether and how these actions relate to the cellular locations of succinate is much warranted. Mechanistically, it is important to consider the sources of succinate, which include somatic cellular released succinate and those produced by the microbiome, especially the gut microbiota, which is an equivalent, if not greater contributor of succinate levels in the body. Continue learning the critical roles of succinate signaling, known and unknown, in many pathophysiological conditions is important. Furthermore, studies to delineate the regulation of succinate levels and to determine how succinate elicits various types of signaling in a temporal and spatial manner are also required.https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-35-36.pdfsuccinatesmicrobiotainflammationsucnr1 proteinperiodontitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuqi Guo Sun Wook Cho Deepak Saxena Xin Li |
spellingShingle |
Yuqi Guo Sun Wook Cho Deepak Saxena Xin Li Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations Endocrinology and Metabolism succinates microbiota inflammation sucnr1 protein periodontitis |
author_facet |
Yuqi Guo Sun Wook Cho Deepak Saxena Xin Li |
author_sort |
Yuqi Guo |
title |
Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations |
title_short |
Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations |
title_full |
Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations |
title_fullStr |
Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations |
title_full_unstemmed |
Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations |
title_sort |
multifaceted actions of succinate as a signaling transmitter vary with its cellular locations |
publisher |
Academya Publishing Co. |
series |
Endocrinology and Metabolism |
issn |
2093-596X 2093-5978 |
publishDate |
2020-03-01 |
description |
Since the identification of succinate's receptor in 2004, studies supporting the involvement of succinate signaling through its receptor in various diseases have accumulated and most of these investigations have highlighted succinate's pro-inflammatory role. Taken with the fact that succinate is an intermediate metabolite in the center of mitochondrial activity, and considering its potential regulation of protein succinylation through succinyl-coenzyme A, a review on the overall multifaceted actions of succinate to discuss whether and how these actions relate to the cellular locations of succinate is much warranted. Mechanistically, it is important to consider the sources of succinate, which include somatic cellular released succinate and those produced by the microbiome, especially the gut microbiota, which is an equivalent, if not greater contributor of succinate levels in the body. Continue learning the critical roles of succinate signaling, known and unknown, in many pathophysiological conditions is important. Furthermore, studies to delineate the regulation of succinate levels and to determine how succinate elicits various types of signaling in a temporal and spatial manner are also required. |
topic |
succinates microbiota inflammation sucnr1 protein periodontitis |
url |
https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-35-36.pdf |
work_keys_str_mv |
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