Neurodevelopmental Disorders: Effect of High-Fat Diet on Synaptic Plasticity and Mitochondrial Functions
Neurodevelopmental disorders (NDDs) include diverse neuropathologies characterized by abnormal brain development leading to impaired cognition, communication and social skills. A common feature of NDDs is defective synaptic plasticity, but the underlying molecular mechanisms are only partially known...
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doaj-03f27b1a5bf140f68600c141cbfc24142020-11-25T02:20:40ZengMDPI AGBrain Sciences2076-34252020-10-011080580510.3390/brainsci10110805Neurodevelopmental Disorders: Effect of High-Fat Diet on Synaptic Plasticity and Mitochondrial FunctionsEduardo Penna0Amelia Pizzella1Fabiano Cimmino2Giovanna Trinchese3Gina Cavaliere4Angela Catapano5Ivana Allocca6Jong Tai Chun7Angelo Campanozzi8Giovanni Messina9Francesco Precenzano10Valentina Lanzara11Antonietta Messina12Vincenzo Monda13Marcellino Monda14Carla Perrone-Capano15Maria Pina Mollica16Marianna Crispino17Department of Biology, University of Naples Federico II, 80126 Naples, ItalyDepartment of Biology, University of Naples Federico II, 80126 Naples, ItalyDepartment of Biology, University of Naples Federico II, 80126 Naples, ItalyDepartment of Biology, University of Naples Federico II, 80126 Naples, ItalyDepartment of Biology, University of Naples Federico II, 80126 Naples, ItalyDepartment of Biology, University of Naples Federico II, 80126 Naples, ItalyDepartment of Biology, University of Naples Federico II, 80126 Naples, ItalyDepartment of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, 80121 Naples, ItalyDepartment of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyDepartment of Mental Health, Physical and Preventive Medicine, Clinic of Child and Adolescent Neuropsychiatry, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Mental Health, Physical and Preventive Medicine, Clinic of Child and Adolescent Neuropsychiatry, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Experimental Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 81100 Caserta, ItalyDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Pharmacy, University of Naples Federico II, 80131 Naples, ItalyDepartment of Biology, University of Naples Federico II, 80126 Naples, ItalyDepartment of Biology, University of Naples Federico II, 80126 Naples, ItalyNeurodevelopmental disorders (NDDs) include diverse neuropathologies characterized by abnormal brain development leading to impaired cognition, communication and social skills. A common feature of NDDs is defective synaptic plasticity, but the underlying molecular mechanisms are only partially known. Several studies have indicated that people’s lifestyles such as diet pattern and physical exercise have significant influence on synaptic plasticity of the brain. Indeed, it has been reported that a high-fat diet (HFD, with 30–50% fat content), which leads to systemic low-grade inflammation, has also a detrimental effect on synaptic efficiency. Interestingly, metabolic alterations associated with obesity in pregnant woman may represent a risk factor for NDDs in the offspring. In this review, we have discussed the potential molecular mechanisms linking the HFD-induced metabolic dysfunctions to altered synaptic plasticity underlying NDDs, with a special emphasis on the roles played by synaptic protein synthesis and mitochondrial functions.https://www.mdpi.com/2076-3425/10/11/805neurodevelopmental disordershigh-fat dietsynaptic plasticitymitochondriasynaptic protein synthesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eduardo Penna Amelia Pizzella Fabiano Cimmino Giovanna Trinchese Gina Cavaliere Angela Catapano Ivana Allocca Jong Tai Chun Angelo Campanozzi Giovanni Messina Francesco Precenzano Valentina Lanzara Antonietta Messina Vincenzo Monda Marcellino Monda Carla Perrone-Capano Maria Pina Mollica Marianna Crispino |
spellingShingle |
Eduardo Penna Amelia Pizzella Fabiano Cimmino Giovanna Trinchese Gina Cavaliere Angela Catapano Ivana Allocca Jong Tai Chun Angelo Campanozzi Giovanni Messina Francesco Precenzano Valentina Lanzara Antonietta Messina Vincenzo Monda Marcellino Monda Carla Perrone-Capano Maria Pina Mollica Marianna Crispino Neurodevelopmental Disorders: Effect of High-Fat Diet on Synaptic Plasticity and Mitochondrial Functions Brain Sciences neurodevelopmental disorders high-fat diet synaptic plasticity mitochondria synaptic protein synthesis |
author_facet |
Eduardo Penna Amelia Pizzella Fabiano Cimmino Giovanna Trinchese Gina Cavaliere Angela Catapano Ivana Allocca Jong Tai Chun Angelo Campanozzi Giovanni Messina Francesco Precenzano Valentina Lanzara Antonietta Messina Vincenzo Monda Marcellino Monda Carla Perrone-Capano Maria Pina Mollica Marianna Crispino |
author_sort |
Eduardo Penna |
title |
Neurodevelopmental Disorders: Effect of High-Fat Diet on Synaptic Plasticity and Mitochondrial Functions |
title_short |
Neurodevelopmental Disorders: Effect of High-Fat Diet on Synaptic Plasticity and Mitochondrial Functions |
title_full |
Neurodevelopmental Disorders: Effect of High-Fat Diet on Synaptic Plasticity and Mitochondrial Functions |
title_fullStr |
Neurodevelopmental Disorders: Effect of High-Fat Diet on Synaptic Plasticity and Mitochondrial Functions |
title_full_unstemmed |
Neurodevelopmental Disorders: Effect of High-Fat Diet on Synaptic Plasticity and Mitochondrial Functions |
title_sort |
neurodevelopmental disorders: effect of high-fat diet on synaptic plasticity and mitochondrial functions |
publisher |
MDPI AG |
series |
Brain Sciences |
issn |
2076-3425 |
publishDate |
2020-10-01 |
description |
Neurodevelopmental disorders (NDDs) include diverse neuropathologies characterized by abnormal brain development leading to impaired cognition, communication and social skills. A common feature of NDDs is defective synaptic plasticity, but the underlying molecular mechanisms are only partially known. Several studies have indicated that people’s lifestyles such as diet pattern and physical exercise have significant influence on synaptic plasticity of the brain. Indeed, it has been reported that a high-fat diet (HFD, with 30–50% fat content), which leads to systemic low-grade inflammation, has also a detrimental effect on synaptic efficiency. Interestingly, metabolic alterations associated with obesity in pregnant woman may represent a risk factor for NDDs in the offspring. In this review, we have discussed the potential molecular mechanisms linking the HFD-induced metabolic dysfunctions to altered synaptic plasticity underlying NDDs, with a special emphasis on the roles played by synaptic protein synthesis and mitochondrial functions. |
topic |
neurodevelopmental disorders high-fat diet synaptic plasticity mitochondria synaptic protein synthesis |
url |
https://www.mdpi.com/2076-3425/10/11/805 |
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