Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape

Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape

Regulatory T (Treg) cells are developed in the thymus, and are essential for suppressing detrimental autoimmunity. Here the authors show, using mice with dampened interleukin 2 (IL-2) signaling, that IL-2 helps position the pioneer factor SATB1 to control genome-wide chromatin accessibility to facil...

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Bibliographic Details
Main Authors: Laurent Chorro, Masako Suzuki, Shu Shien Chin, Tere M. Williams, Erik L. Snapp, Livia Odagiu, Nathalie Labrecque, Grégoire Lauvau
Format: Article
Language:English
Published: Nature Publishing Group 2018-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07806-6

Internet

https://doi.org/10.1038/s41467-018-07806-6

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