Clinical, Diagnostic, and Therapeutic Aspects of Growth Hormone Deficiency During the Transition Period: Review of the Literature

The role of growth hormone (GH) during childhood and adulthood is well established. Once final stature is reached, GH continues to act during the transition, the period between adolescence and adulthood in which most somatic and psychological development is obtained. The achievement of peak bone mas...

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Main Authors:	Matteo Spaziani, Chiara Tarantino, Natascia Tahani, Daniele Gianfrilli, Emilia Sbardella, Andrea M. Isidori, Andrea Lenzi, Antonio F. Radicioni
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-02-01
Series:	Frontiers in Endocrinology
Subjects:	transition period bone body composition metabolism gonad function growth hormone deficiency
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2021.634288/full

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spelling	doaj-03fbf8e6c24f48bc9519cca99a3b3cbc2021-02-24T06:14:03ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-02-011210.3389/fendo.2021.634288634288Clinical, Diagnostic, and Therapeutic Aspects of Growth Hormone Deficiency During the Transition Period: Review of the LiteratureMatteo Spaziani0Matteo Spaziani1Chiara Tarantino2Chiara Tarantino3Natascia Tahani4Daniele Gianfrilli5Emilia Sbardella6Andrea M. Isidori7Andrea Lenzi8Antonio F. Radicioni9Antonio F. Radicioni10Section of Medical Pathophysiology and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Rome, ItalyCentre for Rare Diseases, Policlinico Umberto I, Rome, ItalySection of Medical Pathophysiology and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Rome, ItalyCentre for Rare Diseases, Policlinico Umberto I, Rome, ItalyDepartment of Diabetes, Endocrinology and Metabolism, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United KingdomSection of Medical Pathophysiology and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Rome, ItalySection of Medical Pathophysiology and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Rome, ItalySection of Medical Pathophysiology and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Rome, ItalySection of Medical Pathophysiology and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Rome, ItalySection of Medical Pathophysiology and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Rome, ItalyCentre for Rare Diseases, Policlinico Umberto I, Rome, ItalyThe role of growth hormone (GH) during childhood and adulthood is well established. Once final stature is reached, GH continues to act during the transition, the period between adolescence and adulthood in which most somatic and psychological development is obtained. The achievement of peak bone mass represents the most relevant aspect of GH action during the transition period; however, equally clear is its influence on body composition and metabolic profile and, probably, in the achievement of a complete gonadal and sexual maturation. Despite this, there are still some aspects that often make clinical practice difficult and uncertain, in particular in evaluating a possible persistence of GH deficiency once final stature has been reached. It is also essential to identify which subjects should undergo re-testing and, possibly, replacement therapy, and the definition of unambiguous criteria for therapeutic success. Moreover, even during the transition phase, the relationship between GH substitution therapy and cancer survival is of considerable interest. In view of the above, the aim of this paper is to clarify these relevant issues through a detailed analysis of the literature, with particular attention to the clinical, diagnostic and therapeutic aspects.https://www.frontiersin.org/articles/10.3389/fendo.2021.634288/fulltransition periodbonebody compositionmetabolismgonad functiongrowth hormone deficiency
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Matteo Spaziani Matteo Spaziani Chiara Tarantino Chiara Tarantino Natascia Tahani Daniele Gianfrilli Emilia Sbardella Andrea M. Isidori Andrea Lenzi Antonio F. Radicioni Antonio F. Radicioni
spellingShingle	Matteo Spaziani Matteo Spaziani Chiara Tarantino Chiara Tarantino Natascia Tahani Daniele Gianfrilli Emilia Sbardella Andrea M. Isidori Andrea Lenzi Antonio F. Radicioni Antonio F. Radicioni Clinical, Diagnostic, and Therapeutic Aspects of Growth Hormone Deficiency During the Transition Period: Review of the Literature Frontiers in Endocrinology transition period bone body composition metabolism gonad function growth hormone deficiency
author_facet	Matteo Spaziani Matteo Spaziani Chiara Tarantino Chiara Tarantino Natascia Tahani Daniele Gianfrilli Emilia Sbardella Andrea M. Isidori Andrea Lenzi Antonio F. Radicioni Antonio F. Radicioni
author_sort	Matteo Spaziani
title	Clinical, Diagnostic, and Therapeutic Aspects of Growth Hormone Deficiency During the Transition Period: Review of the Literature
title_short	Clinical, Diagnostic, and Therapeutic Aspects of Growth Hormone Deficiency During the Transition Period: Review of the Literature
title_full	Clinical, Diagnostic, and Therapeutic Aspects of Growth Hormone Deficiency During the Transition Period: Review of the Literature
title_fullStr	Clinical, Diagnostic, and Therapeutic Aspects of Growth Hormone Deficiency During the Transition Period: Review of the Literature
title_full_unstemmed	Clinical, Diagnostic, and Therapeutic Aspects of Growth Hormone Deficiency During the Transition Period: Review of the Literature
title_sort	clinical, diagnostic, and therapeutic aspects of growth hormone deficiency during the transition period: review of the literature
publisher	Frontiers Media S.A.
series	Frontiers in Endocrinology
issn	1664-2392
publishDate	2021-02-01
description	The role of growth hormone (GH) during childhood and adulthood is well established. Once final stature is reached, GH continues to act during the transition, the period between adolescence and adulthood in which most somatic and psychological development is obtained. The achievement of peak bone mass represents the most relevant aspect of GH action during the transition period; however, equally clear is its influence on body composition and metabolic profile and, probably, in the achievement of a complete gonadal and sexual maturation. Despite this, there are still some aspects that often make clinical practice difficult and uncertain, in particular in evaluating a possible persistence of GH deficiency once final stature has been reached. It is also essential to identify which subjects should undergo re-testing and, possibly, replacement therapy, and the definition of unambiguous criteria for therapeutic success. Moreover, even during the transition phase, the relationship between GH substitution therapy and cancer survival is of considerable interest. In view of the above, the aim of this paper is to clarify these relevant issues through a detailed analysis of the literature, with particular attention to the clinical, diagnostic and therapeutic aspects.
topic	transition period bone body composition metabolism gonad function growth hormone deficiency
url	https://www.frontiersin.org/articles/10.3389/fendo.2021.634288/full
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Clinical, Diagnostic, and Therapeutic Aspects of Growth Hormone Deficiency During the Transition Period: Review of the Literature

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