Late complications of clinical clostridium histolyticum collagenase use in Dupuytren's disease.
<h4>Introduction</h4>While Dupuytren's disease can cause disabling contractures requiring open surgery, a less-invasive option using Clostridium Histolyticum collagenase (CHC) via percutaneous injection was recently reported. A recent prospective, randomized trial demonstrated few c...
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doaj-04002241ef1741cca7591f8fa249087b2021-03-04T00:25:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0178e4340610.1371/journal.pone.0043406Late complications of clinical clostridium histolyticum collagenase use in Dupuytren's disease.Warren M RozenYasith EdirisingheJohn Crock<h4>Introduction</h4>While Dupuytren's disease can cause disabling contractures requiring open surgery, a less-invasive option using Clostridium Histolyticum collagenase (CHC) via percutaneous injection was recently reported. A recent prospective, randomized trial demonstrated few complications during 90 days follow-up, however did not assess any longer term follow-up for these patients. Long-term outcomes in this setting have not been adequately reported, and the current manuscript aims to identify late complications from the clinical use of percutaneous CHC.<h4>Methods</h4>The current manuscript reports an extended 12-month follow-up for a cohort of twelve of patients enrolled in the original prospective, randomized trial, treated at a single institution. An analysis of complications requiring surgical intervention was undertaken.<h4>Results</h4>Two of twelve patients reported debilitating pain and triggering requiring surgical intervention. Extensive deep-tissue scarring and adhesions were identified, providing the first visual and qualitative analysis of the pathologic effects of CHC.<h4>Conclusion</h4>Late complications from CHC use can and have occurred, outside the follow-up period of the initial phase III trials. Longer term follow-up of such patients is thus essential, and further investigation and characterization of the late effects of CHC use is warranted.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22912868/pdf/?tool=EBI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Warren M Rozen Yasith Edirisinghe John Crock |
spellingShingle |
Warren M Rozen Yasith Edirisinghe John Crock Late complications of clinical clostridium histolyticum collagenase use in Dupuytren's disease. PLoS ONE |
author_facet |
Warren M Rozen Yasith Edirisinghe John Crock |
author_sort |
Warren M Rozen |
title |
Late complications of clinical clostridium histolyticum collagenase use in Dupuytren's disease. |
title_short |
Late complications of clinical clostridium histolyticum collagenase use in Dupuytren's disease. |
title_full |
Late complications of clinical clostridium histolyticum collagenase use in Dupuytren's disease. |
title_fullStr |
Late complications of clinical clostridium histolyticum collagenase use in Dupuytren's disease. |
title_full_unstemmed |
Late complications of clinical clostridium histolyticum collagenase use in Dupuytren's disease. |
title_sort |
late complications of clinical clostridium histolyticum collagenase use in dupuytren's disease. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2012-01-01 |
description |
<h4>Introduction</h4>While Dupuytren's disease can cause disabling contractures requiring open surgery, a less-invasive option using Clostridium Histolyticum collagenase (CHC) via percutaneous injection was recently reported. A recent prospective, randomized trial demonstrated few complications during 90 days follow-up, however did not assess any longer term follow-up for these patients. Long-term outcomes in this setting have not been adequately reported, and the current manuscript aims to identify late complications from the clinical use of percutaneous CHC.<h4>Methods</h4>The current manuscript reports an extended 12-month follow-up for a cohort of twelve of patients enrolled in the original prospective, randomized trial, treated at a single institution. An analysis of complications requiring surgical intervention was undertaken.<h4>Results</h4>Two of twelve patients reported debilitating pain and triggering requiring surgical intervention. Extensive deep-tissue scarring and adhesions were identified, providing the first visual and qualitative analysis of the pathologic effects of CHC.<h4>Conclusion</h4>Late complications from CHC use can and have occurred, outside the follow-up period of the initial phase III trials. Longer term follow-up of such patients is thus essential, and further investigation and characterization of the late effects of CHC use is warranted. |
url |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22912868/pdf/?tool=EBI |
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