Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control Study
Adherence to healthy dietary guidelines has been related to a lower risk of several cancers, but its role in primary liver cancer (PLC) has not been fully investigated, especially among Eastern populations. This study enrolled 720 PLC patients and 720 healthy controls who were frequency-matched by a...
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doaj-04098c08be5f4ec9865d795ccd4cd08e2020-11-25T00:53:41ZengMDPI AGNutrients2072-66432018-08-01108111310.3390/nu10081113nu10081113Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control StudyPei-Yan Chen0Ai-Ping Fang1Xiao-Yan Wang2Qiu-Ye Lan3Gong-Cheng Liao4Zhao-Yan Liu5Dao-Ming Zhang6Yao-Yun Zhang7Yu-Ming Chen8Hui-Lian Zhu9Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Hepatobiliary Surgery, Sun Yat-sen University Cancer Center, Guangzhou 510060, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition and Health; Guangzhou 510080, ChinaDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaAdherence to healthy dietary guidelines has been related to a lower risk of several cancers, but its role in primary liver cancer (PLC) has not been fully investigated, especially among Eastern populations. This study enrolled 720 PLC patients and 720 healthy controls who were frequency-matched by age and sex between September 2013 and October 2017 in South China. Dietary quality was assessed by the Chinese Healthy Eating Index (CHEI) and the Healthy Eating Index 2015 (HEI-2015), which manifests as scores of adhering to the 2016 Dietary Guidelines for Chinese and adhering to the 2015–2020 Dietary Guidelines for Americans, respectively. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models, adjusting for potential confounders. Higher scores in both the CHEI and HEI-2015 were associated with a lower risk of PLC (per 5-points increment of the total scores: OR: 0.43, 95% CI: 0.38–0.50 for CHEI; OR: 0.47, 95% CI: 0.40–0.55 for HEI-2015). The protective associations persisted significantly in the stratified analyses by sex, smoker status, alcohol consumption, HBV infection, and histological types of PLC, without statistical evidence for heterogeneity (p-interaction > 0.05). Closer adherence to the most recent dietary guidelines for Chinese or Americans may protect against PLC.http://www.mdpi.com/2072-6643/10/8/1113dietary indexdietliver cancerrisk factorscase-control study |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pei-Yan Chen Ai-Ping Fang Xiao-Yan Wang Qiu-Ye Lan Gong-Cheng Liao Zhao-Yan Liu Dao-Ming Zhang Yao-Yun Zhang Yu-Ming Chen Hui-Lian Zhu |
spellingShingle |
Pei-Yan Chen Ai-Ping Fang Xiao-Yan Wang Qiu-Ye Lan Gong-Cheng Liao Zhao-Yan Liu Dao-Ming Zhang Yao-Yun Zhang Yu-Ming Chen Hui-Lian Zhu Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control Study Nutrients dietary index diet liver cancer risk factors case-control study |
author_facet |
Pei-Yan Chen Ai-Ping Fang Xiao-Yan Wang Qiu-Ye Lan Gong-Cheng Liao Zhao-Yan Liu Dao-Ming Zhang Yao-Yun Zhang Yu-Ming Chen Hui-Lian Zhu |
author_sort |
Pei-Yan Chen |
title |
Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control Study |
title_short |
Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control Study |
title_full |
Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control Study |
title_fullStr |
Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control Study |
title_full_unstemmed |
Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control Study |
title_sort |
adherence to the chinese or american dietary guidelines is associated with a lower risk of primary liver cancer in china: a case-control study |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2018-08-01 |
description |
Adherence to healthy dietary guidelines has been related to a lower risk of several cancers, but its role in primary liver cancer (PLC) has not been fully investigated, especially among Eastern populations. This study enrolled 720 PLC patients and 720 healthy controls who were frequency-matched by age and sex between September 2013 and October 2017 in South China. Dietary quality was assessed by the Chinese Healthy Eating Index (CHEI) and the Healthy Eating Index 2015 (HEI-2015), which manifests as scores of adhering to the 2016 Dietary Guidelines for Chinese and adhering to the 2015–2020 Dietary Guidelines for Americans, respectively. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models, adjusting for potential confounders. Higher scores in both the CHEI and HEI-2015 were associated with a lower risk of PLC (per 5-points increment of the total scores: OR: 0.43, 95% CI: 0.38–0.50 for CHEI; OR: 0.47, 95% CI: 0.40–0.55 for HEI-2015). The protective associations persisted significantly in the stratified analyses by sex, smoker status, alcohol consumption, HBV infection, and histological types of PLC, without statistical evidence for heterogeneity (p-interaction > 0.05). Closer adherence to the most recent dietary guidelines for Chinese or Americans may protect against PLC. |
topic |
dietary index diet liver cancer risk factors case-control study |
url |
http://www.mdpi.com/2072-6643/10/8/1113 |
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