Metabolic Insight of Neutrophils in Health and Disease
Neutrophils are the most abundant, short lived, and terminally differentiated leukocytes with distinct tiers of arsenals to counter pathogens. Neutrophils were traditionally considered transcriptionally inactive cells, but recent researches in the field led to a paradigm shift in neutrophil biology...
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Frontiers Media S.A.
2019-09-01
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doaj-040b6bdbd65b4da999e6d725773335a22020-11-24T20:44:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-09-011010.3389/fimmu.2019.02099450783Metabolic Insight of Neutrophils in Health and DiseaseSachin Kumar0Madhu Dikshit1Pharmacology Division, CSIR-Central Drug Research Institute, Lucknow, IndiaTranslational Health Science and Technology Institute, Faridabad, IndiaNeutrophils are the most abundant, short lived, and terminally differentiated leukocytes with distinct tiers of arsenals to counter pathogens. Neutrophils were traditionally considered transcriptionally inactive cells, but recent researches in the field led to a paradigm shift in neutrophil biology and revealed subpopulation heterogeneity, and functions pivotal to immunity and inflammation. Furthermore, recent unfolding of metabolic plasticity in neutrophils has challenged the long-standing concept of their sole dependence on glycolytic pathway. Metabolic adaptations and distinct regulations have been identified which are critical for neutrophil differentiation and functions. The metabolic reprogramming of neutrophils by inflammatory mediators or during pathologies such as sepsis, diabetes, glucose-6-phosphate dehydrogenase deficiency, glycogen storage diseases (GSDs), systemic lupus erythematosus (SLE), rheumatoid arthritis, and cancer are now being explored. In this review, we discuss recent developments in understanding of the metabolic regulation, that may provide clues for better management and newer therapeutic opportunities for neutrophil centric immuno-deficiencies and inflammatory disorders.https://www.frontiersin.org/article/10.3389/fimmu.2019.02099/fullneutrophil functionsglycolysisTCA cyclepentose phosphate pathwayglutaminolysisfatty acid oxidation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sachin Kumar Madhu Dikshit |
spellingShingle |
Sachin Kumar Madhu Dikshit Metabolic Insight of Neutrophils in Health and Disease Frontiers in Immunology neutrophil functions glycolysis TCA cycle pentose phosphate pathway glutaminolysis fatty acid oxidation |
author_facet |
Sachin Kumar Madhu Dikshit |
author_sort |
Sachin Kumar |
title |
Metabolic Insight of Neutrophils in Health and Disease |
title_short |
Metabolic Insight of Neutrophils in Health and Disease |
title_full |
Metabolic Insight of Neutrophils in Health and Disease |
title_fullStr |
Metabolic Insight of Neutrophils in Health and Disease |
title_full_unstemmed |
Metabolic Insight of Neutrophils in Health and Disease |
title_sort |
metabolic insight of neutrophils in health and disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2019-09-01 |
description |
Neutrophils are the most abundant, short lived, and terminally differentiated leukocytes with distinct tiers of arsenals to counter pathogens. Neutrophils were traditionally considered transcriptionally inactive cells, but recent researches in the field led to a paradigm shift in neutrophil biology and revealed subpopulation heterogeneity, and functions pivotal to immunity and inflammation. Furthermore, recent unfolding of metabolic plasticity in neutrophils has challenged the long-standing concept of their sole dependence on glycolytic pathway. Metabolic adaptations and distinct regulations have been identified which are critical for neutrophil differentiation and functions. The metabolic reprogramming of neutrophils by inflammatory mediators or during pathologies such as sepsis, diabetes, glucose-6-phosphate dehydrogenase deficiency, glycogen storage diseases (GSDs), systemic lupus erythematosus (SLE), rheumatoid arthritis, and cancer are now being explored. In this review, we discuss recent developments in understanding of the metabolic regulation, that may provide clues for better management and newer therapeutic opportunities for neutrophil centric immuno-deficiencies and inflammatory disorders. |
topic |
neutrophil functions glycolysis TCA cycle pentose phosphate pathway glutaminolysis fatty acid oxidation |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2019.02099/full |
work_keys_str_mv |
AT sachinkumar metabolicinsightofneutrophilsinhealthanddisease AT madhudikshit metabolicinsightofneutrophilsinhealthanddisease |
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