Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets

Epigenetic and transcriptional dynamics are critical for both tissue homeostasis and injury response in the kidney. Leveraging a single cell multiomics atlas of the developing mouse kidney, the authors reveal key events in chromatin regulation and gene expression dynamics during postnatal developmen...

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Main Authors:	Zhen Miao, Michael S. Balzer, Ziyuan Ma, Hongbo Liu, Junnan Wu, Rojesh Shrestha, Tamas Aranyi, Amy Kwan, Ayano Kondo, Marco Pontoglio, Junhyong Kim, Mingyao Li, Klaus H. Kaestner, Katalin Susztak
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-22266-1

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spelling	doaj-041359208fd74d1f952a6f800451b64e2021-04-18T11:14:26ZengNature Publishing GroupNature Communications2041-17232021-04-0112111710.1038/s41467-021-22266-1Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targetsZhen Miao0Michael S. Balzer1Ziyuan Ma2Hongbo Liu3Junnan Wu4Rojesh Shrestha5Tamas Aranyi6Amy Kwan7Ayano Kondo8Marco Pontoglio9Junhyong Kim10Mingyao Li11Klaus H. Kaestner12Katalin Susztak13Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of MedicineRenal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of MedicineRenal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of MedicineRenal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of MedicineRenal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of MedicineRenal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of MedicineRenal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of MedicineDepartment of Genetics, University of Pennsylvania, Perelman School of MedicineDepartment of Genetics, University of Pennsylvania, Perelman School of MedicineEpigenetics and Development Laboratory, Université de Paris Inserm U1151/CNRS UMR 8253, Institut Necker Enfants MaladesDepartment of Biology, University of PennsylvaniaDepartment of Epidemiology and Biostatistics, University of Pennsylvania, Perelman School of MedicineInstitute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Perelman School of MedicineRenal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of MedicineEpigenetic and transcriptional dynamics are critical for both tissue homeostasis and injury response in the kidney. Leveraging a single cell multiomics atlas of the developing mouse kidney, the authors reveal key events in chromatin regulation and gene expression dynamics during postnatal development.https://doi.org/10.1038/s41467-021-22266-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zhen Miao Michael S. Balzer Ziyuan Ma Hongbo Liu Junnan Wu Rojesh Shrestha Tamas Aranyi Amy Kwan Ayano Kondo Marco Pontoglio Junhyong Kim Mingyao Li Klaus H. Kaestner Katalin Susztak
spellingShingle	Zhen Miao Michael S. Balzer Ziyuan Ma Hongbo Liu Junnan Wu Rojesh Shrestha Tamas Aranyi Amy Kwan Ayano Kondo Marco Pontoglio Junhyong Kim Mingyao Li Klaus H. Kaestner Katalin Susztak Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets Nature Communications
author_facet	Zhen Miao Michael S. Balzer Ziyuan Ma Hongbo Liu Junnan Wu Rojesh Shrestha Tamas Aranyi Amy Kwan Ayano Kondo Marco Pontoglio Junhyong Kim Mingyao Li Klaus H. Kaestner Katalin Susztak
author_sort	Zhen Miao
title	Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets
title_short	Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets
title_full	Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets
title_fullStr	Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets
title_full_unstemmed	Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets
title_sort	single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-04-01
description	Epigenetic and transcriptional dynamics are critical for both tissue homeostasis and injury response in the kidney. Leveraging a single cell multiomics atlas of the developing mouse kidney, the authors reveal key events in chromatin regulation and gene expression dynamics during postnatal development.
url	https://doi.org/10.1038/s41467-021-22266-1
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Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets

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