Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer development

Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer development

Abstract Background Cancer cells are characterized by chromosomal instability (CIN) and it is thought that errors in pathways involved in faithful chromosome segregation play a pivotal role in the genesis of CIN. Cohesin forms a large protein ring that binds DNA strands by encircling them. In additi...

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Bibliographic Details
Main Authors: Patrizia Sarogni, Orazio Palumbo, Adele Servadio, Simonetta Astigiano, Barbara D’Alessio, Veronica Gatti, Dubravka Cukrov, Silvia Baldari, Maria Michela Pallotta, Paolo Aretini, Felice Dell’Orletta, Silvia Soddu, Massimo Carella, Gabriele Toietta, Ottavia Barbieri, Gabriella Fontanini, Antonio Musio
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cohesin
SMC1A
Chromosome instability
Gene expression dysregulation
Human colorectal cancer development
Online Access:http://link.springer.com/article/10.1186/s13046-019-1116-0

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