Mistletoe in the treatment of malignant melanoma
Malignant melanoma is a malignant neoplasia drives from melanocytes. Malignant melanoma, the most causing death, is seen in the third place at skin cancer. Malignant melanoma shows intrinsic resistance to chemotherapeutic agents and variability in the course of the disease which are distinct feature...
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doaj-041ccef1940d4c029ba230dc801995e02021-09-02T04:32:18ZengModestum Publishing LTDJournal of Clinical and Experimental Investigations1309-85781309-66212014-03-015114515210.5799/ahinjs.01.2014.01.0380Mistletoe in the treatment of malignant melanomaEsin Sakallı Çetin0Pınar Aslan Koşar1Nurten Özçelik2Department of Medical Biology, School of Medicine, Muğla Sıtkı Koçman University, 48100, Muğla, TurkeyDepartment of Medical Biology, School of Medicine, Süleyman Demirel University, 32260, Isparta, TurkeyDepartment of Medical Biology, School of Medicine, Süleyman Demirel University, 32260, Isparta, TurkeyMalignant melanoma is a malignant neoplasia drives from melanocytes. Malignant melanoma, the most causing death, is seen in the third place at skin cancer. Malignant melanoma shows intrinsic resistance to chemotherapeutic agents and variability in the course of the disease which are distinct features separating from other solid tumors. These features prevent the development and standardization of non-surgical treatment models of malignant melanoma. Although there is a large number of chemotherapeutic agents used in the treatment of metastatic malignant melanoma, it hasn’t been demonstrated the survival advantage of adjuvant treatment with chemotherapeutic agents. Because of the different clinical course of malignant melanoma, the disease is thought to be closely associated with immune system. Therefore, immunomodulatory therapy models were developed. Mistletoe stimulates the immune system by increasing the number and activity of dendritic cells, thus it has been shown to effect on tumor growth and metastasis of malignant melanoma patient. Outlined in this review are the recent developments in the understanding the role of mistletoe as a complementary therapy for malignant melanoma. J Clin Exp Invest 2014; 5 (1): 145-152http://www.jceionline.org/upload/sayi/20/JCEI-00859.pdfMalignant melanomamistletoe |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Esin Sakallı Çetin Pınar Aslan Koşar Nurten Özçelik |
spellingShingle |
Esin Sakallı Çetin Pınar Aslan Koşar Nurten Özçelik Mistletoe in the treatment of malignant melanoma Journal of Clinical and Experimental Investigations Malignant melanoma mistletoe |
author_facet |
Esin Sakallı Çetin Pınar Aslan Koşar Nurten Özçelik |
author_sort |
Esin Sakallı Çetin |
title |
Mistletoe in the treatment of malignant melanoma |
title_short |
Mistletoe in the treatment of malignant melanoma |
title_full |
Mistletoe in the treatment of malignant melanoma |
title_fullStr |
Mistletoe in the treatment of malignant melanoma |
title_full_unstemmed |
Mistletoe in the treatment of malignant melanoma |
title_sort |
mistletoe in the treatment of malignant melanoma |
publisher |
Modestum Publishing LTD |
series |
Journal of Clinical and Experimental Investigations |
issn |
1309-8578 1309-6621 |
publishDate |
2014-03-01 |
description |
Malignant melanoma is a malignant neoplasia drives from melanocytes. Malignant melanoma, the most causing death, is seen in the third place at skin cancer. Malignant melanoma shows intrinsic resistance to chemotherapeutic agents and variability in the course of the disease which are distinct features separating from other solid tumors. These features prevent the development and standardization of non-surgical treatment models of malignant melanoma. Although there is a large number of chemotherapeutic agents used in the treatment of metastatic malignant melanoma, it hasn’t been demonstrated the survival advantage of adjuvant treatment with chemotherapeutic agents. Because of the different clinical course of malignant melanoma, the disease is thought to be closely associated with immune system. Therefore, immunomodulatory therapy models were developed. Mistletoe stimulates the immune system by increasing the number and activity of dendritic cells, thus it has been shown to effect on tumor growth and metastasis of malignant melanoma patient. Outlined in this review are the recent developments in the understanding the role of mistletoe as a complementary therapy for malignant melanoma. J Clin Exp Invest 2014; 5 (1): 145-152 |
topic |
Malignant melanoma mistletoe |
url |
http://www.jceionline.org/upload/sayi/20/JCEI-00859.pdf |
work_keys_str_mv |
AT esinsakallıcetin mistletoeinthetreatmentofmalignantmelanoma AT pınaraslankosar mistletoeinthetreatmentofmalignantmelanoma AT nurtenozcelik mistletoeinthetreatmentofmalignantmelanoma |
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1721180013910294528 |