P.46 Assessment of Intraplaque Hemorrhage by Photoacoustics Imaging (PAI): First in-vivo Human Validation Study
Aim: To validate a photoacoustic imaging (PAI) system, for the identification of intraplaque hemorrhage, comparing it with MRI and histology (gold standard). Methods: 25 patients with carotid stenosis >70% and clinical indication to tromboendoarterectomy were recruited. Angio-MRI for intrapl...
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doaj-0422ddedcbdf4a6b958afc8823f080262021-02-01T15:05:24ZengAtlantis PressArtery Research 1876-44012020-12-0126Supplement 110.2991/artres.k.201209.058P.46 Assessment of Intraplaque Hemorrhage by Photoacoustics Imaging (PAI): First in-vivo Human Validation StudyRosa Maria BrunoYuki ImaizumiHasan ObeidMichael JaegerPierre JuliaPatrick BrunevalDavid CalvetAim: To validate a photoacoustic imaging (PAI) system, for the identification of intraplaque hemorrhage, comparing it with MRI and histology (gold standard). Methods: 25 patients with carotid stenosis >70% and clinical indication to tromboendoarterectomy were recruited. Angio-MRI for intraplaque hemorrhage assessment (Cube sequence) was performed. PAI clips (5 seconds, Frame rate 1000/sec, 3 to 15 per patient) were acquired. Each clip was scored for the presence of PAI signal by means of an integrated scoring system (semiquantitative, from 0 to 12). Semiquantitative grading scales were used to assess plaque histological features of hemorrhage and vulnerability. Results: 18 patients had no missing MRI, PAI and histology data and were included in this analysis. Mean age was 73 ± 8 years, 60% men, 80% Caucasians, 92% hypertensives, 60% with a previous stroke. At histology, only 3 plaques out of 21 showed no signs of intraplaque hemorrhage, 4 showed small hemorrhage, while 14 (67%) showed large hemorrhages. PAI score (best cut-off ≥ 4) correctly classified 14 out of 18 patients (Sensitivity = 73.3%, specificity = 100%, AUC = 0.867). MRI performance was substantially similar, with 12 patients correctly classified (sensitivity = 60%, specificity = 100%, AUC = 0.800), with a non-significant difference in AUC compared to PAI (p = 0.420). Conclusions: In this first in-vivo human study, PAI is able to identify histological intraplaque hemorrhage with an excellent specificity and acceptable sensitivity, equivalent to MRI. The very high specificity, with a low number of false positives, make PAI a good candidate for evaluation of plaques prior to surgery to i.e. reinforce the decision to perform surgery.https://www.atlantis-press.com/article/125950079/viewCarotid-plaquephotoacousticvalidation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rosa Maria Bruno Yuki Imaizumi Hasan Obeid Michael Jaeger Pierre Julia Patrick Bruneval David Calvet |
spellingShingle |
Rosa Maria Bruno Yuki Imaizumi Hasan Obeid Michael Jaeger Pierre Julia Patrick Bruneval David Calvet P.46 Assessment of Intraplaque Hemorrhage by Photoacoustics Imaging (PAI): First in-vivo Human Validation Study Artery Research Carotid-plaque photoacoustic validation |
author_facet |
Rosa Maria Bruno Yuki Imaizumi Hasan Obeid Michael Jaeger Pierre Julia Patrick Bruneval David Calvet |
author_sort |
Rosa Maria Bruno |
title |
P.46 Assessment of Intraplaque Hemorrhage by Photoacoustics Imaging (PAI): First in-vivo Human Validation Study |
title_short |
P.46 Assessment of Intraplaque Hemorrhage by Photoacoustics Imaging (PAI): First in-vivo Human Validation Study |
title_full |
P.46 Assessment of Intraplaque Hemorrhage by Photoacoustics Imaging (PAI): First in-vivo Human Validation Study |
title_fullStr |
P.46 Assessment of Intraplaque Hemorrhage by Photoacoustics Imaging (PAI): First in-vivo Human Validation Study |
title_full_unstemmed |
P.46 Assessment of Intraplaque Hemorrhage by Photoacoustics Imaging (PAI): First in-vivo Human Validation Study |
title_sort |
p.46 assessment of intraplaque hemorrhage by photoacoustics imaging (pai): first in-vivo human validation study |
publisher |
Atlantis Press |
series |
Artery Research |
issn |
1876-4401 |
publishDate |
2020-12-01 |
description |
Aim: To validate a photoacoustic imaging (PAI) system, for the identification of intraplaque hemorrhage, comparing it with MRI and histology (gold standard).
Methods: 25 patients with carotid stenosis >70% and clinical indication to tromboendoarterectomy were recruited. Angio-MRI for intraplaque hemorrhage assessment (Cube sequence) was performed. PAI clips (5 seconds, Frame rate 1000/sec, 3 to 15 per patient) were acquired. Each clip was scored for the presence of PAI signal by means of an integrated scoring system (semiquantitative, from 0 to 12). Semiquantitative grading scales were used to assess plaque histological features of hemorrhage and vulnerability.
Results: 18 patients had no missing MRI, PAI and histology data and were included in this analysis. Mean age was 73 ± 8 years, 60% men, 80% Caucasians, 92% hypertensives, 60% with a previous stroke. At histology, only 3 plaques out of 21 showed no signs of intraplaque hemorrhage, 4 showed small hemorrhage, while 14 (67%) showed large hemorrhages. PAI score (best cut-off ≥ 4) correctly classified 14 out of 18 patients (Sensitivity = 73.3%, specificity = 100%, AUC = 0.867). MRI performance was substantially similar, with 12 patients correctly classified (sensitivity = 60%, specificity = 100%, AUC = 0.800), with a non-significant difference in AUC compared to PAI (p = 0.420).
Conclusions: In this first in-vivo human study, PAI is able to identify histological intraplaque hemorrhage with an excellent specificity and acceptable sensitivity, equivalent to MRI. The very high specificity, with a low number of false positives, make PAI a good candidate for evaluation of plaques prior to surgery to i.e. reinforce the decision to perform surgery. |
topic |
Carotid-plaque photoacoustic validation |
url |
https://www.atlantis-press.com/article/125950079/view |
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