TCR and CD28 Concomitant Stimulation Elicits a Distinctive Calcium Response in Naive T Cells

TCR and CD28 Concomitant Stimulation Elicits a Distinctive Calcium Response in Naive T Cells

T cell activation is initiated upon ligand engagement of the T cell receptor (TCR) and costimulatory receptors. The CD28 molecule acts as a major costimulatory receptor in promoting full activation of naive T cells. However, despite extensive studies, why naive T cell activation requires concurrent...

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Bibliographic Details
Main Authors: Fan Xia, Cheng-Rui Qian, Zhou Xun, Yannick Hamon, Anne-Marie Sartre, Anthony Formisano, Sébastien Mailfert, Marie-Claire Phelipot, Cyrille Billaudeau, Sébastien Jaeger, Jacques A. Nunès, Xiao-Jun Guo, Hai-Tao He
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
T cell activation
naive T cells
co-stimulation
CD28
TCR–T cell receptor
calcium signaling
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02864/full

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