Effect of buprenorphine transdermal patch combined with patientcontrolled intravenous analgesia on the serum pain-related biochemical indexes in elderly patients with intertrochanteric fracture
Objective: To study the effect of buprenorphine transdermal patch combined with patientcontrolled intravenous analgesia on the serum pain-related biochemical indexes in elderly patients with intertrochanteric fracture. Methods: A total of 92 elderly patients with intertrochanteric fracture who re...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2017-09-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201717/17.pdf |
Summary: | Objective: To study the effect of buprenorphine transdermal patch combined with patientcontrolled
intravenous analgesia on the serum pain-related biochemical indexes in elderly
patients with intertrochanteric fracture. Methods: A total of 92 elderly patients with
intertrochanteric fracture who received surgical treatment in the hospital between August
2014 and January 2017 were collected and divided into control group (n=46) and observation
group (n=46) according to the random number table method. The control group received
patient-controlled intravenous analgesia, and the observation group received buprenorphine
transdermal patch combined with patient-controlled intravenous analgesia. Differences in
serum levels of inflammatory factors, oxidative stress indexes and pain mediators of two
groups of patients were measured before and 24h after surgery. Results: Differences in
serum levels of inflammatory factors, oxidative stress indexes and pain mediators were not
statistically significant between the two groups before surgery; 24 h after surgery, serum IL-
1β, IL-6, IL-8, TNF-α, MDA, SP, PGE2, 5-HT, HA and NPY levels of both groups of
patients increased significantly while SOD, TAC and CAT levels decreased significantly, and
serum IL-1β, IL-6, IL-8, TNF-α, MDA, SP, PGE2, 5-HT, HA and NPY levels of observation
group were lower than those of control group while SOD, TAC and CAT levels were higher
than those of control group. Conclusion: Buprenorphine transdermal patch combined with
patient-controlled intravenous analgesia can effectively inhibit the expression of pain-related
indexes and relieve early postoperative pain intensity in elderly patients with intertrochanteric
fracture. |
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ISSN: | 1007-1237 1007-1237 |