Tolerance to FVIII: Role of the Immune Metabolic Enzymes Indoleamine 2,3 Dyoxigenase-1 and Heme Oxygenase-1

Tolerance to FVIII: Role of the Immune Metabolic Enzymes Indoleamine 2,3 Dyoxigenase-1 and Heme Oxygenase-1

The occurrence of neutralizing anti-FVIII antibodies is a major complication in the treatment of patients affected by hemophilia A. The immune response to FVIII is a complex, multi-factorial process that has been extensively studied for the past two decades. The reasons why only a proportion of hemo...

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Bibliographic Details
Main Authors: Davide Matino, Sajjad Afraz, George Zhao, Paul Tieu, Marco Gargaro, Francesca Fallarino, Alfonso Iorio
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
hemophilia
inhibitor
danger model
FVIII
IDO
HO-1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00620/full

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