Effects of milk supplementation with conjugated linoleic acid on weight control and body composition in healthy overweight people
Introduction: Conjugated linoleic acids (CLAs) have shown beneficial effects in weight control therapy however this relation is not clear. Objetive: The aim of the study was to examine the effects and safety of 3 g of a 1:1 mix of c9-t11 and t10-c12 on weight control and body composition in healthy...
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Arán Ediciones, S. L.
2013-12-01
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doaj-04285a6b74c64d99b5392f470e8752702020-11-25T02:21:59ZengArán Ediciones, S. L.Nutrición Hospitalaria0212-16112013-12-012862090209810.3305/nh.2013.28.6.7013S0212-16112013000600039Effects of milk supplementation with conjugated linoleic acid on weight control and body composition in healthy overweight peopleBrida López-Plaza0Laura M. Bermejo1Thabata Koester Weber2Pilar Parra3Francisca Serra4Marta Hernández5Samara Palma Milla6Carmen Gómez-Candela7La Paz University HospitalLa Paz University HospitalLa Paz University HospitalUniversity of the Balearic IslandsUniversity of the Balearic IslandsCorporación Alimentaria Peña Santa, SA. (CAPSA)La Paz University HospitalLa Paz University HospitalIntroduction: Conjugated linoleic acids (CLAs) have shown beneficial effects in weight control therapy however this relation is not clear. Objetive: The aim of the study was to examine the effects and safety of 3 g of a 1:1 mix of c9-t11 and t10-c12 on weight control and body composition in healthy overweight individuals. Methods: A prospective, placebo-controlled, randomised double-blind, parallel clinical trial lasting 24 weeks was carried out in 38 volunteers (29w, 9m) aged 30-55 years and BMI ≥ 27 -<30 kg/m² who consumed 200 ml/day of skimmed milk with 3g of CLAs or 3g olive oil (placebo). Anthropometric, biochemical and dual x-ray absorptiometry (DXA) tests were measured. Diet and physical activity were assessed. Results: Subjects maintained their habitual dietary and exercise patterns over the study. Only CLA group showed a significant decrease in weight (74.43 ± 10.45 vs 73.54 ± 11.66 kg, p = 0.029) and waist circumference (91.45 ± 10.33 vs 90.65 ± 9.84 cm, p = 0.012) between baseline and end of the study. BMI and waist height ratio decreased (28.44 ± 1.08 vs 27.81 ± 1.43 kg/m², p = 0.030 and 0.57 ± 0.05 vs 0.56 ± 0.04 p = 0.013 respectively) in CLA group at the end. CLA group experienced a reduction in total fat mass after 24 weeks (38.62 ± 5.02 vs 36.65 ± 5.64%, p = 0.035). No decrease was observed in Control group. HOMA index had no changes. Conclusions: The consumption of skimmed milk enriched with 3g of a 1:1 mixture of c9-t11 and t10-c12 for 24 weeks led to a decrease in body weight and total fat mass in healthy, overweight subjects who maintained habitual diets and exercise patterns. No adverse effects were observed. Registered under ClinicalTrials.gov Identifier No. NCT01503047.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112013000600039&lng=en&tlng=enÁcido linoleico conjugadoSobrepesoPérdida de pesoAbsorciometría Dual de Rayos XEnsayos clínicos |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Brida López-Plaza Laura M. Bermejo Thabata Koester Weber Pilar Parra Francisca Serra Marta Hernández Samara Palma Milla Carmen Gómez-Candela |
spellingShingle |
Brida López-Plaza Laura M. Bermejo Thabata Koester Weber Pilar Parra Francisca Serra Marta Hernández Samara Palma Milla Carmen Gómez-Candela Effects of milk supplementation with conjugated linoleic acid on weight control and body composition in healthy overweight people Nutrición Hospitalaria Ácido linoleico conjugado Sobrepeso Pérdida de peso Absorciometría Dual de Rayos X Ensayos clínicos |
author_facet |
Brida López-Plaza Laura M. Bermejo Thabata Koester Weber Pilar Parra Francisca Serra Marta Hernández Samara Palma Milla Carmen Gómez-Candela |
author_sort |
Brida López-Plaza |
title |
Effects of milk supplementation with conjugated linoleic acid on weight control and body composition in healthy overweight people |
title_short |
Effects of milk supplementation with conjugated linoleic acid on weight control and body composition in healthy overweight people |
title_full |
Effects of milk supplementation with conjugated linoleic acid on weight control and body composition in healthy overweight people |
title_fullStr |
Effects of milk supplementation with conjugated linoleic acid on weight control and body composition in healthy overweight people |
title_full_unstemmed |
Effects of milk supplementation with conjugated linoleic acid on weight control and body composition in healthy overweight people |
title_sort |
effects of milk supplementation with conjugated linoleic acid on weight control and body composition in healthy overweight people |
publisher |
Arán Ediciones, S. L. |
series |
Nutrición Hospitalaria |
issn |
0212-1611 |
publishDate |
2013-12-01 |
description |
Introduction: Conjugated linoleic acids (CLAs) have shown beneficial effects in weight control therapy however this relation is not clear. Objetive: The aim of the study was to examine the effects and safety of 3 g of a 1:1 mix of c9-t11 and t10-c12 on weight control and body composition in healthy overweight individuals. Methods: A prospective, placebo-controlled, randomised double-blind, parallel clinical trial lasting 24 weeks was carried out in 38 volunteers (29w, 9m) aged 30-55 years and BMI ≥ 27 -<30 kg/m² who consumed 200 ml/day of skimmed milk with 3g of CLAs or 3g olive oil (placebo). Anthropometric, biochemical and dual x-ray absorptiometry (DXA) tests were measured. Diet and physical activity were assessed. Results: Subjects maintained their habitual dietary and exercise patterns over the study. Only CLA group showed a significant decrease in weight (74.43 ± 10.45 vs 73.54 ± 11.66 kg, p = 0.029) and waist circumference (91.45 ± 10.33 vs 90.65 ± 9.84 cm, p = 0.012) between baseline and end of the study. BMI and waist height ratio decreased (28.44 ± 1.08 vs 27.81 ± 1.43 kg/m², p = 0.030 and 0.57 ± 0.05 vs 0.56 ± 0.04 p = 0.013 respectively) in CLA group at the end. CLA group experienced a reduction in total fat mass after 24 weeks (38.62 ± 5.02 vs 36.65 ± 5.64%, p = 0.035). No decrease was observed in Control group. HOMA index had no changes. Conclusions: The consumption of skimmed milk enriched with 3g of a 1:1 mixture of c9-t11 and t10-c12 for 24 weeks led to a decrease in body weight and total fat mass in healthy, overweight subjects who maintained habitual diets and exercise patterns. No adverse effects were observed. Registered under ClinicalTrials.gov Identifier No. NCT01503047. |
topic |
Ácido linoleico conjugado Sobrepeso Pérdida de peso Absorciometría Dual de Rayos X Ensayos clínicos |
url |
http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112013000600039&lng=en&tlng=en |
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