Genetic alterations in head and neck squamous cell carcinomas
The genetic alterations observed in head and neck cancer are mainly due to oncogene activation (gain of function mutations) and tumor suppressor gene inactivation (loss of function mutations), leading to deregulation of cell proliferation and death. These genetic alterations include gene amplificati...
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Associação Brasileira de Divulgação Científica
1999-01-01
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Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700015 |
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doaj-04333cf5cb3b4203a410d25f27e466bf2020-11-24T23:21:52ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X0034-73101999-01-01327897904Genetic alterations in head and neck squamous cell carcinomasNagai M.A.The genetic alterations observed in head and neck cancer are mainly due to oncogene activation (gain of function mutations) and tumor suppressor gene inactivation (loss of function mutations), leading to deregulation of cell proliferation and death. These genetic alterations include gene amplification and overexpression of oncogenes such as myc, erbB-2, EGFR and cyclinD1 and mutations, deletions and hypermethylation leading to p16 and TP53 tumor suppressor gene inactivation. In addition, loss of heterozygosity in several chromosomal regions is frequently observed, suggesting that other tumor suppressor genes not yet identified could be involved in the tumorigenic process of head and neck cancers. The exact temporal sequence of the genetic alterations during head and neck squamous cell carcinoma (HNSCC) development and progression has not yet been defined and their diagnostic or prognostic significance is controversial. Advances in the understanding of the molecular basis of head and neck cancer should help in the identification of new markers that could be used for the diagnosis, prognosis and treatment of the disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700015genetic alterationsoncogenetumor suppressor genehead and neck cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nagai M.A. |
spellingShingle |
Nagai M.A. Genetic alterations in head and neck squamous cell carcinomas Brazilian Journal of Medical and Biological Research genetic alterations oncogene tumor suppressor gene head and neck cancer |
author_facet |
Nagai M.A. |
author_sort |
Nagai M.A. |
title |
Genetic alterations in head and neck squamous cell carcinomas |
title_short |
Genetic alterations in head and neck squamous cell carcinomas |
title_full |
Genetic alterations in head and neck squamous cell carcinomas |
title_fullStr |
Genetic alterations in head and neck squamous cell carcinomas |
title_full_unstemmed |
Genetic alterations in head and neck squamous cell carcinomas |
title_sort |
genetic alterations in head and neck squamous cell carcinomas |
publisher |
Associação Brasileira de Divulgação Científica |
series |
Brazilian Journal of Medical and Biological Research |
issn |
0100-879X 0034-7310 |
publishDate |
1999-01-01 |
description |
The genetic alterations observed in head and neck cancer are mainly due to oncogene activation (gain of function mutations) and tumor suppressor gene inactivation (loss of function mutations), leading to deregulation of cell proliferation and death. These genetic alterations include gene amplification and overexpression of oncogenes such as myc, erbB-2, EGFR and cyclinD1 and mutations, deletions and hypermethylation leading to p16 and TP53 tumor suppressor gene inactivation. In addition, loss of heterozygosity in several chromosomal regions is frequently observed, suggesting that other tumor suppressor genes not yet identified could be involved in the tumorigenic process of head and neck cancers. The exact temporal sequence of the genetic alterations during head and neck squamous cell carcinoma (HNSCC) development and progression has not yet been defined and their diagnostic or prognostic significance is controversial. Advances in the understanding of the molecular basis of head and neck cancer should help in the identification of new markers that could be used for the diagnosis, prognosis and treatment of the disease. |
topic |
genetic alterations oncogene tumor suppressor gene head and neck cancer |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700015 |
work_keys_str_mv |
AT nagaima geneticalterationsinheadandnecksquamouscellcarcinomas |
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