Induction of ER stress in macrophages of tuberculosis granulomas.
The endoplasmic reticulum (ER) stress pathway known as the Unfolded Protein Response (UPR) is an adaptive survival pathway that protects cells from the buildup of misfolded proteins, but under certain circumstances it can lead to apoptosis. ER stress has been causally associated with macrophage apop...
Main Authors: | Tracie A Seimon, Mi-Jeong Kim, Antje Blumenthal, Jovanka Koo, Sabine Ehrt, Helen Wainwright, Linda-Gail Bekker, Gilla Kaplan, Carl Nathan, Ira Tabas, David G Russell |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-09-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2939897?pdf=render |
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