Rhinovirus C Infection Induces Type 2 Innate Lymphoid Cell Expansion and Eosinophilic Airway Inflammation

Rhinovirus C Infection Induces Type 2 Innate Lymphoid Cell Expansion and Eosinophilic Airway Inflammation

Rhinovirus C (RV-C) infection is associated with severe asthma exacerbations. Since type 2 inflammation is an important disease mechanism in asthma, we hypothesized that RV-C infection, in contrast to RV-A, preferentially stimulates type 2 inflammation, leading to exacerbated eosinophilic inflammati...

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Bibliographic Details
Main Authors: Charu Rajput, Mingyuan Han, Tomoko Ishikawa, Jing Lei, Adam M. Goldsmith, Seyedehzarifeh Jazaeri, Claudia C. Stroupe, J. Kelley Bentley, Marc B. Hershenson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
asthma
rhinovirus
innate cytokine
viral infection
exacerbation
ILC2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.649520/full

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