IS HYPERURICEMIA A COMPONENT OF THE METABOLIC SYNDROME?
The aim of the study was to assess the presence and extent of hyperuricemia in patients with metabolic syndrome features of various severity, as well as possible relationship between altered purin metabolism and other components of the syndrome. We enrolled 97 patients suffering essential hypertensi...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2001-02-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/2165 |
| Summary: | The aim of the study was to assess the presence and extent of hyperuricemia in patients with metabolic syndrome features of various severity, as well as possible relationship between altered purin metabolism and other components of the syndrome. We enrolled 97 patients suffering essential hypertension with a various number of metabolic syndrome components and without such and 13 normotensive patients with metabolic syndrome. Insulin, carbohydrate, lipid and purin metabolism were studied and echo was done in all the patients.Uric acid concentration in patients with metabolic syndrome correlated reliably with the parameters of obesity, values of insulin metabolism, triglyceridemia, glycemia and renin-angiotensin-aldosterone system activity. Uric acid level of 415 мM and higher occurred reliably more often in patients with the clinical picture of the “deadly quartet” than in hypertensives without insulin resistance. Hyperuricemia in metabolic syndrome accompanied alterations in lipid metabolism and progressed with the severity of the metabolic syndrome itself.We conclude that hyperuricemia is an alteration of metabolism characteristic of the syndrome of insulin resistance and suggest it be viewed as an integral component of the metabolic syndrome. |
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| ISSN: | 1560-4071 2618-7620 |