Integrated Analysis Reveals Altered Lipid and Glucose Metabolism and Identifies NOTCH2 as a Biomarker for Parkinson's Disease Related Depression

Integrated Analysis Reveals Altered Lipid and Glucose Metabolism and Identifies NOTCH2 as a Biomarker for Parkinson's Disease Related Depression

Depression is a common comorbidity in Parkinson's disease (PD) but is underdiagnosed. We aim to investigate the altered metabolic pathways of Parkinson's disease-related depression (PDD) in plasma and to identify potential biomarkers for clinical diagnosis. Consecutive patients with PD wer...

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Bibliographic Details
Main Authors: Mei-Xue Dong, Xia Feng, Xiao-Min Xu, Ling Hu, Yang Liu, Si-Yu Jia, Bo Li, Wei Chen, You-Dong Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Parkinson's disease
depression
proteomics
metabolomics
integrated analysis
biomarker
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00257/full

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