Advance in Targeted Immunotherapy for Graft-Versus-Host Disease
Graft-versus-host disease (GVHD) is a serious and deadly complication of patients, who undergo hematopoietic stem cell transplantation (HSCT). Despite prophylactic treatment with immunosuppressive agents, 20–80% of recipients develop acute GVHD after HSCT. And the incidence rates of chronic GVHD ran...
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doaj-045353a460fd46788ee39b770f04ab9a2020-11-25T00:02:46ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-05-01910.3389/fimmu.2018.01087362803Advance in Targeted Immunotherapy for Graft-Versus-Host DiseaseLingling Zhang0Jianhua Yu1Wei Wei2Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immunopharmacology of Education, Ministry of China, Anti-Inflammatory Immune Drugs Collaborative Innovation Center, Hefei, Anhui, ChinaDivision of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, United StatesInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immunopharmacology of Education, Ministry of China, Anti-Inflammatory Immune Drugs Collaborative Innovation Center, Hefei, Anhui, ChinaGraft-versus-host disease (GVHD) is a serious and deadly complication of patients, who undergo hematopoietic stem cell transplantation (HSCT). Despite prophylactic treatment with immunosuppressive agents, 20–80% of recipients develop acute GVHD after HSCT. And the incidence rates of chronic GVHD range from 6 to 80%. Standard therapeutic strategies are still lacking, although considerable advances have been gained in knowing of the predisposing factors, pathology, and diagnosis of GVHD. Targeting immune cells, such as regulatory T cells, as well as tolerogenic dendritic cells or mesenchymal stromal cells (MSCs) display considerable benefit in the relief of GVHD through the deletion of alloactivated T cells. Monoclonal antibodies targeting cytokines or signaling molecules have been demonstrated to be beneficial for the prevention of GVHD. However, these remain to be verified in clinical therapy. It is also important and necessary to consider adopting individualized treatment based on GVHD subtypes, pathological mechanisms involved and stages. In the future, it is hoped that the identification of novel therapeutic targets and systematic research strategies may yield novel safe and effective approaches in clinic to improve outcomes of GVHD further. In this article, we reviewed the current advances in targeted immunotherapy for the prevention of GVHD.http://journal.frontiersin.org/article/10.3389/fimmu.2018.01087/fullgraft-versus-host diseaseimmunotherapyimmune inhibitorsimmune cellshematopoietic stem cell transplantation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lingling Zhang Jianhua Yu Wei Wei |
spellingShingle |
Lingling Zhang Jianhua Yu Wei Wei Advance in Targeted Immunotherapy for Graft-Versus-Host Disease Frontiers in Immunology graft-versus-host disease immunotherapy immune inhibitors immune cells hematopoietic stem cell transplantation |
author_facet |
Lingling Zhang Jianhua Yu Wei Wei |
author_sort |
Lingling Zhang |
title |
Advance in Targeted Immunotherapy for Graft-Versus-Host Disease |
title_short |
Advance in Targeted Immunotherapy for Graft-Versus-Host Disease |
title_full |
Advance in Targeted Immunotherapy for Graft-Versus-Host Disease |
title_fullStr |
Advance in Targeted Immunotherapy for Graft-Versus-Host Disease |
title_full_unstemmed |
Advance in Targeted Immunotherapy for Graft-Versus-Host Disease |
title_sort |
advance in targeted immunotherapy for graft-versus-host disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2018-05-01 |
description |
Graft-versus-host disease (GVHD) is a serious and deadly complication of patients, who undergo hematopoietic stem cell transplantation (HSCT). Despite prophylactic treatment with immunosuppressive agents, 20–80% of recipients develop acute GVHD after HSCT. And the incidence rates of chronic GVHD range from 6 to 80%. Standard therapeutic strategies are still lacking, although considerable advances have been gained in knowing of the predisposing factors, pathology, and diagnosis of GVHD. Targeting immune cells, such as regulatory T cells, as well as tolerogenic dendritic cells or mesenchymal stromal cells (MSCs) display considerable benefit in the relief of GVHD through the deletion of alloactivated T cells. Monoclonal antibodies targeting cytokines or signaling molecules have been demonstrated to be beneficial for the prevention of GVHD. However, these remain to be verified in clinical therapy. It is also important and necessary to consider adopting individualized treatment based on GVHD subtypes, pathological mechanisms involved and stages. In the future, it is hoped that the identification of novel therapeutic targets and systematic research strategies may yield novel safe and effective approaches in clinic to improve outcomes of GVHD further. In this article, we reviewed the current advances in targeted immunotherapy for the prevention of GVHD. |
topic |
graft-versus-host disease immunotherapy immune inhibitors immune cells hematopoietic stem cell transplantation |
url |
http://journal.frontiersin.org/article/10.3389/fimmu.2018.01087/full |
work_keys_str_mv |
AT linglingzhang advanceintargetedimmunotherapyforgraftversushostdisease AT jianhuayu advanceintargetedimmunotherapyforgraftversushostdisease AT weiwei advanceintargetedimmunotherapyforgraftversushostdisease |
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1725436700141813760 |