Can Na18F PET/CT Be Used to Study Bone Remodeling in the Tibia When Patients Are Being Treated with a Taylor Spatial Frame?
Monitoring and quantifying bone remodeling are of interest, for example, in correction osteotomies, delayed fracture healing pseudarthrosis, bone lengthening, and other instances. Seven patients who had operations to attach an Ilizarov-derived Taylor Spatial Frame to the tibia gave informed consent....
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doaj-0458d339cb8f4972b79e7c46216f8db02020-11-25T00:51:26ZengHindawi LimitedThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/249326249326Can Na18F PET/CT Be Used to Study Bone Remodeling in the Tibia When Patients Are Being Treated with a Taylor Spatial Frame?Henrik Lundblad0Gerald Q. Maguire1Henrik Olivecrona2Cathrine Jonsson3Hans Jacobsson4Marilyn E. Noz5Michael P. Zeleznik6Lars Weidenhielm7Anders Sundin8Department of Molecular Medicine and Surgery, Section of Orthopaedics and Sports Medicine, Karolinska Institute, A2:07, 171 76 Stockholm, SwedenSchool of Information and Communication Technology, KTH Royal Institute of Technology, Isafjordsgatan 26, 418 164-40 Stockholm, SwedenDepartment of Molecular Medicine and Surgery, Section of Orthopaedics and Sports Medicine, Karolinska Institute, A2:07, 171 76 Stockholm, SwedenDepartment of Hospital Physics, Karolinska University Hospital, 17 176 Solna, Stockholm, SwedenDepartment of Molecular Medicine and Surgery, Section of Orthopaedics and Sports Medicine, Karolinska Institute, A2:07, 171 76 Stockholm, SwedenDepartment of Radiology, New York University, 550 First Avenue, THW232, New York, NY 10016, USASchool of Computing, College of Engineering, University of Utah, 50 Central Campus Dr., Room 3190, Salt Lake City, UT 84112, USADepartment of Molecular Medicine and Surgery, Section of Orthopaedics and Sports Medicine, Karolinska Institute, A2:07, 171 76 Stockholm, SwedenDepartment of Molecular Medicine and Surgery, Section of Orthopaedics and Sports Medicine, Karolinska Institute, A2:07, 171 76 Stockholm, SwedenMonitoring and quantifying bone remodeling are of interest, for example, in correction osteotomies, delayed fracture healing pseudarthrosis, bone lengthening, and other instances. Seven patients who had operations to attach an Ilizarov-derived Taylor Spatial Frame to the tibia gave informed consent. Each patient was examined by Na18F PET/CT twice, at approximately six weeks and three months after the operation. A validated software tool was used for the following processing steps. The first and second CT volumes were aligned in 3D and the respective PET volumes were aligned accordingly. In the first PET volume spherical volumes of interest (VOIs) were delineated for the crural fracture and normal bone and transferred to the second PET volume for SUVmax evaluation. This method potentially provides clinical insight into questions such as, when has the bone remodeling progressed well enough to safely remove the TSF? and when is intervention required, in a timelier manner than current methods? For example, in two patients who completed treatment, the SUVmax between the first and second PET/CT examination decreased by 42% and 13%, respectively. Further studies in a larger patient population are needed to verify these preliminary results by correlating regional Na18F PET measurements to clinical and radiological findings.http://dx.doi.org/10.1155/2014/249326 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Henrik Lundblad Gerald Q. Maguire Henrik Olivecrona Cathrine Jonsson Hans Jacobsson Marilyn E. Noz Michael P. Zeleznik Lars Weidenhielm Anders Sundin |
spellingShingle |
Henrik Lundblad Gerald Q. Maguire Henrik Olivecrona Cathrine Jonsson Hans Jacobsson Marilyn E. Noz Michael P. Zeleznik Lars Weidenhielm Anders Sundin Can Na18F PET/CT Be Used to Study Bone Remodeling in the Tibia When Patients Are Being Treated with a Taylor Spatial Frame? The Scientific World Journal |
author_facet |
Henrik Lundblad Gerald Q. Maguire Henrik Olivecrona Cathrine Jonsson Hans Jacobsson Marilyn E. Noz Michael P. Zeleznik Lars Weidenhielm Anders Sundin |
author_sort |
Henrik Lundblad |
title |
Can Na18F PET/CT Be Used to Study Bone Remodeling in the Tibia When Patients Are Being Treated with a Taylor Spatial Frame? |
title_short |
Can Na18F PET/CT Be Used to Study Bone Remodeling in the Tibia When Patients Are Being Treated with a Taylor Spatial Frame? |
title_full |
Can Na18F PET/CT Be Used to Study Bone Remodeling in the Tibia When Patients Are Being Treated with a Taylor Spatial Frame? |
title_fullStr |
Can Na18F PET/CT Be Used to Study Bone Remodeling in the Tibia When Patients Are Being Treated with a Taylor Spatial Frame? |
title_full_unstemmed |
Can Na18F PET/CT Be Used to Study Bone Remodeling in the Tibia When Patients Are Being Treated with a Taylor Spatial Frame? |
title_sort |
can na18f pet/ct be used to study bone remodeling in the tibia when patients are being treated with a taylor spatial frame? |
publisher |
Hindawi Limited |
series |
The Scientific World Journal |
issn |
2356-6140 1537-744X |
publishDate |
2014-01-01 |
description |
Monitoring and quantifying bone remodeling are of interest, for example, in correction osteotomies, delayed fracture healing pseudarthrosis, bone lengthening, and other instances. Seven patients who had operations to attach an Ilizarov-derived Taylor Spatial Frame to the tibia gave informed consent. Each patient was examined by Na18F PET/CT twice, at approximately six weeks and three months after the operation. A validated software tool was used for the following processing steps. The first and second CT volumes were aligned in 3D and the respective PET volumes were aligned accordingly. In the first PET volume spherical volumes of interest (VOIs) were delineated for the crural fracture and normal bone and transferred to the second PET volume for SUVmax evaluation. This method potentially provides clinical insight into questions such as, when has the bone remodeling progressed well enough to safely remove the TSF? and when is intervention required, in a timelier manner than current methods? For example, in two patients who completed treatment, the SUVmax between the first and second PET/CT examination decreased by 42% and 13%, respectively. Further studies in a larger patient population are needed to verify these preliminary results by correlating regional Na18F PET measurements to clinical and radiological findings. |
url |
http://dx.doi.org/10.1155/2014/249326 |
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