Synthesis and Determination of Physicochemical Properties of New 3-(4-Arylpiperazin-1-yl)-2-hydroxypropyl 4-Alkoxyethoxybenzoates

Synthesis and Determination of Physicochemical Properties of New 3-(4-Arylpiperazin-1-yl)-2-hydroxypropyl 4-Alkoxyethoxybenzoates

Nine new dihydrochloride salts of 3-(4-arylpiperazin-1-yl)-2-hydroxypropyl 4-alkoxyethoxybenzoates were designed and synthesized. The physicochemical properties such as lipophilicity index (log kw) and dissociation constant (pKa) were experimentally determined and compared to the software calculated...

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Bibliographic Details
Main Authors: Pavlina Marvanova, Tereza Padrtova, Klara Odehnalova, Ondrej Hosik, Michal Oravec, Petr Mokry
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Molecules
Subjects:
arylcarbonyloxyaminopropanols
phenylpiperazines
pKa determination
lipophilicity index
Lipinski rules
blood–brain barrier
Online Access:http://www.mdpi.com/1420-3049/21/12/1682

Internet

http://www.mdpi.com/1420-3049/21/12/1682

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