Oleuropein reduces anxiety-like responses by activating of serotonergic and neuropeptide Y (NPY)-ergic systems in a rat model of post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by traumatic experiences. This psychopathological response to traumatic stressors induces anxiety in rats. Oleuropein (OLE), a major compound in olive leaves, reportedly possesses several pharmacological properties, inc...
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doaj-0461376f9e204ba0916eb8f46ef33a922020-11-24T22:14:51ZengTaylor & Francis GroupAnimal Cells and Systems1976-83542151-24852018-03-0122210911710.1080/19768354.2018.14266991426699Oleuropein reduces anxiety-like responses by activating of serotonergic and neuropeptide Y (NPY)-ergic systems in a rat model of post-traumatic stress disorderBombi Lee0Insop Shim1Hyejung Lee2Dae-Hyun Hahm3Kyung Hee UniversityKyung Hee UniversityKyung Hee UniversityKyung Hee UniversityPost-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by traumatic experiences. This psychopathological response to traumatic stressors induces anxiety in rats. Oleuropein (OLE), a major compound in olive leaves, reportedly possesses several pharmacological properties, including anti-cancer, anti-diabetic, and anti-atherosclerotic and neuropsychiatric activities. However, the anxiolytic-like effects of OLE and its mechanism of action in PTSD are unclear. The present study used several behavioral tests to examine the effects of OLE on symptoms of anxiety in rats after a single prolonged stress (SPS) exposure by inhibiting the hypothalamic-pituitary-adrenal axis. Male Sprague Dawley rats received OLE (10, 50 and 70 mg/kg, i.p., once daily) for 14 days after SPS exposure. Daily OLE (70 mg/kg) administration significantly increased the number and duration of open arm visits in the elevated plus maze (EPM) test, reduced the anxiety index and grooming behavior in the EPM test, and increased the time spent and number of central zone crossings in the open field test. OLE also blocked the SPS-induced decrease in hippocampal serotonin and neuropeptide Y expression in hippocampus. These findings suggest that OLE has anxiolytic-like effects on behavioral and biochemical symptoms similar to those observed in patients with PTSD.http://dx.doi.org/10.1080/19768354.2018.1426699Oleuropeinpost-traumatic stress disordersingle prolonged stressanxietyserotonin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bombi Lee Insop Shim Hyejung Lee Dae-Hyun Hahm |
spellingShingle |
Bombi Lee Insop Shim Hyejung Lee Dae-Hyun Hahm Oleuropein reduces anxiety-like responses by activating of serotonergic and neuropeptide Y (NPY)-ergic systems in a rat model of post-traumatic stress disorder Animal Cells and Systems Oleuropein post-traumatic stress disorder single prolonged stress anxiety serotonin |
author_facet |
Bombi Lee Insop Shim Hyejung Lee Dae-Hyun Hahm |
author_sort |
Bombi Lee |
title |
Oleuropein reduces anxiety-like responses by activating of serotonergic and neuropeptide Y (NPY)-ergic systems in a rat model of post-traumatic stress disorder |
title_short |
Oleuropein reduces anxiety-like responses by activating of serotonergic and neuropeptide Y (NPY)-ergic systems in a rat model of post-traumatic stress disorder |
title_full |
Oleuropein reduces anxiety-like responses by activating of serotonergic and neuropeptide Y (NPY)-ergic systems in a rat model of post-traumatic stress disorder |
title_fullStr |
Oleuropein reduces anxiety-like responses by activating of serotonergic and neuropeptide Y (NPY)-ergic systems in a rat model of post-traumatic stress disorder |
title_full_unstemmed |
Oleuropein reduces anxiety-like responses by activating of serotonergic and neuropeptide Y (NPY)-ergic systems in a rat model of post-traumatic stress disorder |
title_sort |
oleuropein reduces anxiety-like responses by activating of serotonergic and neuropeptide y (npy)-ergic systems in a rat model of post-traumatic stress disorder |
publisher |
Taylor & Francis Group |
series |
Animal Cells and Systems |
issn |
1976-8354 2151-2485 |
publishDate |
2018-03-01 |
description |
Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by traumatic experiences. This psychopathological response to traumatic stressors induces anxiety in rats. Oleuropein (OLE), a major compound in olive leaves, reportedly possesses several pharmacological properties, including anti-cancer, anti-diabetic, and anti-atherosclerotic and neuropsychiatric activities. However, the anxiolytic-like effects of OLE and its mechanism of action in PTSD are unclear. The present study used several behavioral tests to examine the effects of OLE on symptoms of anxiety in rats after a single prolonged stress (SPS) exposure by inhibiting the hypothalamic-pituitary-adrenal axis. Male Sprague Dawley rats received OLE (10, 50 and 70 mg/kg, i.p., once daily) for 14 days after SPS exposure. Daily OLE (70 mg/kg) administration significantly increased the number and duration of open arm visits in the elevated plus maze (EPM) test, reduced the anxiety index and grooming behavior in the EPM test, and increased the time spent and number of central zone crossings in the open field test. OLE also blocked the SPS-induced decrease in hippocampal serotonin and neuropeptide Y expression in hippocampus. These findings suggest that OLE has anxiolytic-like effects on behavioral and biochemical symptoms similar to those observed in patients with PTSD. |
topic |
Oleuropein post-traumatic stress disorder single prolonged stress anxiety serotonin |
url |
http://dx.doi.org/10.1080/19768354.2018.1426699 |
work_keys_str_mv |
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