Bactericidal antibiotics induce programmed metabolic toxicity
The misuse of antibiotics has led to the development and spread of antibiotic resistance in clinically important pathogens. These resistant infections are having a significant impact on treatment outcomes and contribute to approximately 25,000 deaths in the U.S. annually. If additional therapeutic o...
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doaj-04676a696e514af1beda3e6adeb959cd2020-11-24T20:44:09ZengShared Science Publishers OGMicrobial Cell2311-26382016-03-013417818010.15698/mic2016.04.493Bactericidal antibiotics induce programmed metabolic toxicityAislinn D. Rowan0Damien J. Cabral1Peter Belenky2Department of Molecular Microbiology and Immunology, Brown University, 171 Meeting Street, Providence, RI 02912.Department of Molecular Microbiology and Immunology, Brown University, 171 Meeting Street, Providence, RI 02912.Department of Molecular Microbiology and Immunology, Brown University, 171 Meeting Street, Providence, RI 02912.The misuse of antibiotics has led to the development and spread of antibiotic resistance in clinically important pathogens. These resistant infections are having a significant impact on treatment outcomes and contribute to approximately 25,000 deaths in the U.S. annually. If additional therapeutic options are not identified, the number of annual deaths is predicted to rise to 317,000 in North America and 10,000,000 worldwide by 2050. Identifying therapeutic methodologies that utilize our antibiotic arsenal more effectively is one potential way to extend the useful lifespan of our current antibiotics. Recent studies have indicated that modulating metabolic activity is one possible strategy that can impact the efficacy of antibiotic therapy. In this review, we will address recent advances in our knowledge about the impacts of bacterial metabolism on antibiotic effectiveness and the impacts of antibiotics on bacterial metabolism. We will particularly focus on two studies, Lobritz, et al. (PNAS, 112(27): 8173-8180) and Belenky et al. (Cell Reports, 13(5): 968–980) that together demonstrate that bactericidal antibiotics induce metabolic perturbations that are linked to and required for bactericidal antibiotic toxicity.http://microbialcell.com/researcharticles/bactericidal-antibiotics-induce-programmed-metabolic-toxicity/antibioticsreactive oxygen species (ROS)metabolismantibiotic resistance and tolerance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aislinn D. Rowan Damien J. Cabral Peter Belenky |
spellingShingle |
Aislinn D. Rowan Damien J. Cabral Peter Belenky Bactericidal antibiotics induce programmed metabolic toxicity Microbial Cell antibiotics reactive oxygen species (ROS) metabolism antibiotic resistance and tolerance |
author_facet |
Aislinn D. Rowan Damien J. Cabral Peter Belenky |
author_sort |
Aislinn D. Rowan |
title |
Bactericidal antibiotics induce programmed metabolic toxicity |
title_short |
Bactericidal antibiotics induce programmed metabolic toxicity |
title_full |
Bactericidal antibiotics induce programmed metabolic toxicity |
title_fullStr |
Bactericidal antibiotics induce programmed metabolic toxicity |
title_full_unstemmed |
Bactericidal antibiotics induce programmed metabolic toxicity |
title_sort |
bactericidal antibiotics induce programmed metabolic toxicity |
publisher |
Shared Science Publishers OG |
series |
Microbial Cell |
issn |
2311-2638 |
publishDate |
2016-03-01 |
description |
The misuse of antibiotics has led to the development and spread of antibiotic resistance in clinically important pathogens. These resistant infections are having a significant impact on treatment outcomes and contribute to approximately 25,000 deaths in the U.S. annually. If additional therapeutic options are not identified, the number of annual deaths is predicted to rise to 317,000 in North America and 10,000,000 worldwide by 2050. Identifying therapeutic methodologies that utilize our antibiotic arsenal more effectively is one potential way to extend the useful lifespan of our current antibiotics. Recent studies have indicated that modulating metabolic activity is one possible strategy that can impact the efficacy of antibiotic therapy. In this review, we will address recent advances in our knowledge about the impacts of bacterial metabolism on antibiotic effectiveness and the impacts of antibiotics on bacterial metabolism. We will particularly focus on two studies, Lobritz, et al. (PNAS, 112(27): 8173-8180) and Belenky et al. (Cell Reports, 13(5): 968–980) that together demonstrate that bactericidal antibiotics induce metabolic perturbations that are linked to and required for bactericidal antibiotic toxicity. |
topic |
antibiotics reactive oxygen species (ROS) metabolism antibiotic resistance and tolerance |
url |
http://microbialcell.com/researcharticles/bactericidal-antibiotics-induce-programmed-metabolic-toxicity/ |
work_keys_str_mv |
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