ASXL3 bridges BRD4 to BAP1 complex and governs enhancer activity in small cell lung cancer
Abstract Background Small cell lung cancer (SCLC) is a more aggressive subtype of lung cancer that often results in rapid tumor growth, early metastasis, and acquired therapeutic resistance. Consequently, such phenotypical characteristics of SCLC set limitations on viable procedural options, making...
Main Authors: | Aileen Patricia Szczepanski, Zibo Zhao, Tori Sosnowski, Young Ah Goo, Elizabeth Thomas Bartom, Lu Wang |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-07-01
|
Series: | Genome Medicine |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13073-020-00760-3 |
Similar Items
-
Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network
by: Yu-Kun Xia, et al.
Published: (2020-07-01) -
Régulation du complexe suppresseur de tumeurs BAP1/ASXL2 par ubiquitination
by: Ahmed, Oumaima
Published: (2018) -
Caveolin-2 is regulated by BRD4 and contributes to cell growth in pancreatic cancer
by: Feng Jiao, et al.
Published: (2020-02-01) -
Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function
by: Adam P. Cribbs, et al.
Published: (2021-02-01) -
BRD4 and Cancer: going beyond transcriptional regulation
by: Benedetta Donati, et al.
Published: (2018-11-01)