Modulation of verbal fluency networks by transcranial direct current stimulation (tDCS) in Parkinson’s disease
Background: Verbal fluency relies on the coordinated activity between left frontal and temporal areas. Patients with Parkinson’s disease (PD) present phonemic and semantic fluency deficits. Recent studies suggest that transcranial direct current stimulation (tDCS) enhances adaptative patterns of bra...
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Format: | Article |
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Elsevier
2013-01-01
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Series: | Brain Stimulation |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1935861X12000149 |
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doaj-04836c23ff774bdc970c6aeba888d66d |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Joana B. Pereira Carme Junqué David Bartrés-Faz Maria J. Martí Roser Sala-Llonch Yarko Compta Carles Falcón Pere Vendrell Álvaro Pascual-Leone Josep Valls-Solé Eduardo Tolosa |
spellingShingle |
Joana B. Pereira Carme Junqué David Bartrés-Faz Maria J. Martí Roser Sala-Llonch Yarko Compta Carles Falcón Pere Vendrell Álvaro Pascual-Leone Josep Valls-Solé Eduardo Tolosa Modulation of verbal fluency networks by transcranial direct current stimulation (tDCS) in Parkinson’s disease Brain Stimulation fMRI ICA Parkinson’s disease tDCS Verbal fluency |
author_facet |
Joana B. Pereira Carme Junqué David Bartrés-Faz Maria J. Martí Roser Sala-Llonch Yarko Compta Carles Falcón Pere Vendrell Álvaro Pascual-Leone Josep Valls-Solé Eduardo Tolosa |
author_sort |
Joana B. Pereira |
title |
Modulation of verbal fluency networks by transcranial direct current stimulation (tDCS) in Parkinson’s disease |
title_short |
Modulation of verbal fluency networks by transcranial direct current stimulation (tDCS) in Parkinson’s disease |
title_full |
Modulation of verbal fluency networks by transcranial direct current stimulation (tDCS) in Parkinson’s disease |
title_fullStr |
Modulation of verbal fluency networks by transcranial direct current stimulation (tDCS) in Parkinson’s disease |
title_full_unstemmed |
Modulation of verbal fluency networks by transcranial direct current stimulation (tDCS) in Parkinson’s disease |
title_sort |
modulation of verbal fluency networks by transcranial direct current stimulation (tdcs) in parkinson’s disease |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2013-01-01 |
description |
Background: Verbal fluency relies on the coordinated activity between left frontal and temporal areas. Patients with Parkinson’s disease (PD) present phonemic and semantic fluency deficits. Recent studies suggest that transcranial direct current stimulation (tDCS) enhances adaptative patterns of brain activity between functionally connected areas. Objective: The aim of this study was to assess the differences in the effects induced by tDCS applied to frontal and temporo-parietal areas on phonemic and semantic fluency functional networks in patients with PD. Method: Sixteen patients were randomized to receive tDCS to left dorsolateral prefrontal cortex (DLPFC) and left temporo-parietal cortex (TPC) in a counterbalanced order. Immediately following stimulation, patients underwent a verbal fluency paradigm inside a fMRI scanner. Changes induced by tDCS in activation and deactivation task-related pattern networks were studied using free-model independent component analyses (ICA). Results: Functional connectivity in verbal fluency and deactivation task-related networks was significantly more enhanced by tDCS to DLPFC than to TPC. In addition, DLPFC tDCS increased performance on the phonemic fluency task, after adjusting for baseline phonemic performance. Conclusions: These findings provide evidence that tDCS to specific brain regions induces changes in large scale functional networks that underlay behavioural effects, and suggest that tDCS might be useful to enhance phonemic fluency in PD. |
topic |
fMRI ICA Parkinson’s disease tDCS Verbal fluency |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X12000149 |
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doaj-04836c23ff774bdc970c6aeba888d66d2021-03-18T04:35:45ZengElsevierBrain Stimulation1935-861X2013-01-01611624Modulation of verbal fluency networks by transcranial direct current stimulation (tDCS) in Parkinson’s diseaseJoana B. Pereira0Carme Junqué1David Bartrés-Faz2Maria J. Martí3Roser Sala-Llonch4Yarko Compta5Carles Falcón6Pere Vendrell7Álvaro Pascual-Leone8Josep Valls-Solé9Eduardo Tolosa10Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, SpainDepartment of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, SpainDepartment of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Corresponding author. Tel.: +34 93 403 44 46; fax: +34 93 403 52 94.Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Parkinson’s disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociencies, Hospital Clínic de Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, SpainDepartment of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, SpainInstitute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Parkinson’s disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociencies, Hospital Clínic de Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, SpainInstitute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, SpainDepartment of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, SpainBerenson-Allen Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Institut Universitari de Neurorehabilitacio Guttmann-UAB, Badalona, SpainInstitute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Laboratori d’Exploracions Neurofuncionals, Hospital Clinic de Barcelona, SpainInstitute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Parkinson’s disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociencies, Hospital Clínic de Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, SpainBackground: Verbal fluency relies on the coordinated activity between left frontal and temporal areas. Patients with Parkinson’s disease (PD) present phonemic and semantic fluency deficits. Recent studies suggest that transcranial direct current stimulation (tDCS) enhances adaptative patterns of brain activity between functionally connected areas. Objective: The aim of this study was to assess the differences in the effects induced by tDCS applied to frontal and temporo-parietal areas on phonemic and semantic fluency functional networks in patients with PD. Method: Sixteen patients were randomized to receive tDCS to left dorsolateral prefrontal cortex (DLPFC) and left temporo-parietal cortex (TPC) in a counterbalanced order. Immediately following stimulation, patients underwent a verbal fluency paradigm inside a fMRI scanner. Changes induced by tDCS in activation and deactivation task-related pattern networks were studied using free-model independent component analyses (ICA). Results: Functional connectivity in verbal fluency and deactivation task-related networks was significantly more enhanced by tDCS to DLPFC than to TPC. In addition, DLPFC tDCS increased performance on the phonemic fluency task, after adjusting for baseline phonemic performance. Conclusions: These findings provide evidence that tDCS to specific brain regions induces changes in large scale functional networks that underlay behavioural effects, and suggest that tDCS might be useful to enhance phonemic fluency in PD.http://www.sciencedirect.com/science/article/pii/S1935861X12000149fMRIICAParkinson’s diseasetDCSVerbal fluency |