Pharmacokinetic drug-drug interaction and their implication in clinical management

• Main Authors: Palleria Caterina, Di Paolo Antonello, Giofrè Chiara, Caglioti Chiara, Leuzzi Giacomo, Siniscalchi Antonio, De Sarro Giovambattista, Gallelli Luca
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2013-01-01
• Series: Journal of Research in Medical Sciences
• Subjects: Absorption; adverse drug reaction; distribution; drug-drug interactions; excretion; metabolism; poly-therapy
• Online Access: http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2013;volume=18;issue=7;spage=601;epage=610;aulast=Caterina
• ISSN: 1735-1995; 1735-7136

Drug-drug interactions (DDIs) are one of the commonest causes of medication error in developed countries, particularly in the elderly due to poly-therapy, with a prevalence of 20-40%. In particular, poly-therapy increases the complexity of therapeutic management and thereby the risk of clinically important DDIs, which can both induce the development of adverse drug reactions or reduce the clinical efficacy. DDIs can be classify into two main groups: pharmacokinetic and pharmacodynamic. In this review, using Medline, PubMed, Embase, Cochrane library and Reference lists we searched articles published until June 30 2012, and we described the mechanism of pharmacokinetic DDIs focusing the interest on their clinical implications.