Enhanced Immune Response Against the Thomsen-Friedenreich Tumor Antigen Using a Bivalent Entirely Carbohydrate Conjugate

Enhanced Immune Response Against the Thomsen-Friedenreich Tumor Antigen Using a Bivalent Entirely Carbohydrate Conjugate

The Thomsen-Friedenreich (TF) antigen is a key target for the development of anticancer vaccines, and this ongoing challenge remains relevant due to the poor immunogenicity of the TF antigen. To overcome this challenge, we adopted a bivalent conjugate design which introduced both the TF antigen and...

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Bibliographic Details
Main Authors: Kristopher A. Kleski, Kevin R. Trabbic, Mengchao Shi, Jean-Paul Bourgault, Peter R. Andreana
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
cancer vaccine
tumor associated carbohydrate antigen
zwitterionic polysaccharide
c-type lectin receptor
multivalent vaccine
Online Access:https://www.mdpi.com/1420-3049/25/6/1319

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