Expanding CAR T cells in human platelet lysate renders T cells with in vivo longevity

Expanding CAR T cells in human platelet lysate renders T cells with in vivo longevity

Abstract Background Pre-clinical and clinical studies have shown that the infusion of CAR T cells with a naive-like (TN) and central memory (TCM) phenotype is associated with prolonged in vivo T cell persistence and superior anti-tumor effects. To optimize the maintenance of such populations during...

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Bibliographic Details
Main Authors: Alejandro Torres Chavez, Mary Kathryn McKenna, Emanuele Canestrari, Christina T. Dann, Carlos A. Ramos, Premal Lulla, Ann M. Leen, Juan F. Vera, Norihiro Watanabe
Format: Article
Language:English
Published: BMJ Publishing Group 2019-11-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
CAR T cells
Persistence
Memory phenotype
Manufacture
Human platelet lysate
Online Access:http://link.springer.com/article/10.1186/s40425-019-0804-9

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