Comparing carotid intima-media thickness in type 2 diabetes between patients with and without retinopathy
Background: Microangiopathy and macroangiopathy frequently coexist in type 2 diabetes mellitus (T2DM). Both types of the vascular complications share traditional risk factors but it is not clear whether the presence of microangiopathy, such as diabetic retinopathy, constitutes a predictor of atheros...
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Tehran University of Medical Sciences
2012-06-01
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doaj-049ad3e8e277472b8afd5a128ee654c72020-11-24T22:42:31ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222012-06-01703150155Comparing carotid intima-media thickness in type 2 diabetes between patients with and without retinopathyNaroi Nejad M0Yousefi M1Nazari H2Ghasempoor A3 Background: Microangiopathy and macroangiopathy frequently coexist in type 2 diabetes mellitus (T2DM). Both types of the vascular complications share traditional risk factors but it is not clear whether the presence of microangiopathy, such as diabetic retinopathy, constitutes a predictor of atherosclerosis in carotid arteries in patients with the disease. In this study we looked for the association between diabetic retinopathy and intima-media thickness in carotid arteries of patients with T2DM. Methods: In this case-control study we examined 100 consecutive patients with T2DM in Rasoul Akram Hospital in Tehran, Iran during 2009-2010. We assessed intima-media thickness of carotid arteries by ultrasonography. All patients underwent ophthalmo-logic examination. Results: Diabetic retinopathy was found in 50 (50%) patients. Intima-media thickness was higher in patients with diabetic retinopathy than those without it (0.77±0.17 mm vs. 0.71±0.2 mm, respectively, P=0.041). Moreover, intima-media thickness was more prevalent in patients with proliferative diabetic retinopathy than patients with non-proliferative form of the disease (0.87±0.16 mm vs. 0.68±0.1 mm, respectively, P<0.001). Conclusion: Diabetic retinopathy seems to be associated with increased intima-media thickness of carotid arteries in T2DM. It may be a common denominator of pathogene-sis of microvascular complications and atherosclerosis in T2DM. Evaluations of carotid arteries are to be done by non-invasive methods such as color Doppler sonography for screening and preventing prospective cereberovascular accidents in patients with diabetic retinopathy, especially proliferative retinopathy, in routine ophthalmological examination of patients with T2DM.http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-131&slc_lang=en&sid=1Carotid intima-media thicknessdiabetesretinopathy |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
Naroi Nejad M Yousefi M Nazari H Ghasempoor A |
spellingShingle |
Naroi Nejad M Yousefi M Nazari H Ghasempoor A Comparing carotid intima-media thickness in type 2 diabetes between patients with and without retinopathy Tehran University Medical Journal Carotid intima-media thickness diabetes retinopathy |
author_facet |
Naroi Nejad M Yousefi M Nazari H Ghasempoor A |
author_sort |
Naroi Nejad M |
title |
Comparing carotid intima-media thickness in type 2 diabetes between patients with and without retinopathy |
title_short |
Comparing carotid intima-media thickness in type 2 diabetes between patients with and without retinopathy |
title_full |
Comparing carotid intima-media thickness in type 2 diabetes between patients with and without retinopathy |
title_fullStr |
Comparing carotid intima-media thickness in type 2 diabetes between patients with and without retinopathy |
title_full_unstemmed |
Comparing carotid intima-media thickness in type 2 diabetes between patients with and without retinopathy |
title_sort |
comparing carotid intima-media thickness in type 2 diabetes between patients with and without retinopathy |
publisher |
Tehran University of Medical Sciences |
series |
Tehran University Medical Journal |
issn |
1683-1764 1735-7322 |
publishDate |
2012-06-01 |
description |
Background: Microangiopathy and macroangiopathy frequently coexist in type 2 diabetes mellitus (T2DM). Both types of the vascular complications share traditional risk factors but it is not clear whether the presence of microangiopathy, such as diabetic retinopathy, constitutes a predictor of atherosclerosis in carotid arteries in patients with the disease. In this study we looked for the association between diabetic retinopathy and intima-media thickness in carotid arteries of patients with T2DM.
Methods: In this case-control study we examined 100 consecutive patients with T2DM in Rasoul Akram Hospital in Tehran, Iran during 2009-2010. We assessed intima-media thickness of carotid arteries by ultrasonography. All patients underwent ophthalmo-logic examination.
Results: Diabetic retinopathy was found in 50 (50%) patients. Intima-media thickness was higher in patients with diabetic retinopathy than those without it (0.77±0.17 mm vs. 0.71±0.2 mm, respectively, P=0.041). Moreover, intima-media thickness was more prevalent in patients with proliferative diabetic retinopathy than patients with non-proliferative form of the disease (0.87±0.16 mm vs. 0.68±0.1 mm, respectively, P<0.001).
Conclusion: Diabetic retinopathy seems to be associated with increased intima-media thickness of carotid arteries in T2DM. It may be a common denominator of pathogene-sis of microvascular complications and atherosclerosis in T2DM. Evaluations of carotid arteries are to be done by non-invasive methods such as color Doppler sonography for screening and preventing prospective cereberovascular accidents in patients with diabetic retinopathy, especially proliferative retinopathy, in routine ophthalmological examination of patients with T2DM. |
topic |
Carotid intima-media thickness diabetes retinopathy |
url |
http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-131&slc_lang=en&sid=1 |
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