[<sup>68</sup>Ga]Ga-PSMA-11: The First FDA-Approved <sup>68</sup>Ga-Radiopharmaceutical for PET Imaging of Prostate Cancer
For the positron emission tomography (PET) imaging of prostate cancer, radiotracers targeting the prostate-specific membrane antigen (PSMA) are nowadays used in clinical practice. Almost 10 years after its discovery, [<sup>68</sup>Ga]Ga-PSMA-11 has been approved in the United States by t...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-07-01
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Series: | Pharmaceuticals |
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Online Access: | https://www.mdpi.com/1424-8247/14/8/713 |
Summary: | For the positron emission tomography (PET) imaging of prostate cancer, radiotracers targeting the prostate-specific membrane antigen (PSMA) are nowadays used in clinical practice. Almost 10 years after its discovery, [<sup>68</sup>Ga]Ga-PSMA-11 has been approved in the United States by the Food and Drug Administration (FDA) as the first <sup>68</sup>Ga-radiopharmaceutical for the PET imaging of PSMA-positive prostate cancer in 2020. This radiopharmaceutical combines the peptidomimetic Glu-NH-CO-NH-Lys(Ahx)-HBED-CC with the radionuclide <sup>68</sup>Ga, enabling specific imaging of tumor cells expressing PSMA. Such a targeting approach may also be used for therapy planning as well as potentially for the evaluation of treatment response. |
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ISSN: | 1424-8247 |