Gene-Environment Interaction in a Conditional NMDAR-Knockout Model of Schizophrenia

Gene-Environment Interaction in a Conditional NMDAR-Knockout Model of Schizophrenia

Interactions between genetic and environmental risk factors take center stage in the pathology of schizophrenia. We assessed if the stressor of reduced environmental enrichment applied in adulthood provokes deficits in the positive, negative or cognitive symptom domains of schizophrenia in a mouse l...

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Bibliographic Details
Main Authors: Alexei M. Bygrave, Simonas Masiulis, Dimitri M. Kullmann, David M. Bannerman, Dennis Kätzel
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
schizophrenia
gene-environment interaction
NMDAR-receptor hypofunction
interneurons
risk factors
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2018.00332/full

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