Molecular determinants underlying functional innovations of TBP and their impact on transcription initiation

Molecular determinants underlying functional innovations of TBP and their impact on transcription initiation

The TATA-box binding protein (TBP) is required for transcription initiation in archaea and eukaryotes. Here the authors delineate how TBP’s function has evolved new functional features through context-dependent interactions with various protein partners.

Bibliographic Details
Main Authors: Charles N. J. Ravarani, Tilman Flock, Sreenivas Chavali, Madhanagopal Anandapadamanaban, M. Madan Babu, Santhanam Balaji
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16182-z
Description
Summary:The TATA-box binding protein (TBP) is required for transcription initiation in archaea and eukaryotes. Here the authors delineate how TBP’s function has evolved new functional features through context-dependent interactions with various protein partners.
ISSN:2041-1723

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