High ratio of triglycerides to hdl-cholesterol predicts extensive coronary disease
An abnormal ratio of triglycerides to HDL-cholesterol (TG/HDL-c) indicates an atherogenic lipid profile and a risk for the development of coronary disease. OBJECTIVE: To investigate the association between lipid levels, specifically TG/HDL-c, and the extent of coronary disease. METHODS: High-risk pa...
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doaj-04a4d69fd995407fb6be2ca9afc8fc162020-11-24T21:27:16ZengFaculdade de Medicina / USPClinics1807-59321980-53222008-01-0163442743210.1590/S1807-59322008000400003High ratio of triglycerides to hdl-cholesterol predicts extensive coronary diseaseProtasio Lemos da LuzDesiderio FavaratoJose Rocha Faria-Neto JuniorPedro LemosAntonio Carlos Palandri ChagasAn abnormal ratio of triglycerides to HDL-cholesterol (TG/HDL-c) indicates an atherogenic lipid profile and a risk for the development of coronary disease. OBJECTIVE: To investigate the association between lipid levels, specifically TG/HDL-c, and the extent of coronary disease. METHODS: High-risk patients (n = 374) submitted for coronary angiography had their lipid variables measured and coronary disease extent scored by the Friesinger index. RESULTS: The subjects consisted of 220 males and 154 females, age 57.2 ± 11.1 years, with total cholesterol of 210± 50.3 mg/dL, triglycerides of 173.8 ± 169.8 mg/dL, HDL-cholesterol (HDL-c) of 40.1 ± 12.8 mg/dL, LDL-cholesterol (LDL-c) of 137.3 ± 46.2 mg/dL, TG/HDL-c of 5.1 ± 5.3, and a Friesinger index of 6.6 ± 4.7. The relationship between the extent of coronary disease (dichotomized by a Friesenger index of 5 and lipid levels (normal vs. abnormal) was statistically significant for the following: triglycerides, odds ratio of 2.02 (1.31-3.1; p = 0.0018); HDL-c, odds ratio of 2.21 (1.42-3.43; p = 0.0005); and TG/HDL-c, odds ratio of 2.01(1.30-3.09; p = 0.0018). However, the relationship was not significant between extent of coronary disease and total cholesterol [1.25 (0.82-1.91; p = 0.33)] or LDL-c [1.47 (0.96-2.25; p = 0.0842)]. The chi-square for linear trends for Friesinger > 4 and lipid quartiles was statistically significant for triglycerides (p = 0.0017), HDL-c (p = 0.0001), and TG/HDL-c (p = 0.0018), but not for total cholesterol (p = 0.393) or LDL-c (p = 0.0568). The multivariate analysis by logistic regression OR gave 1.3 ± 0.79 (p = .0001) for TG/HDL-c, 0.779 ± 0.074 (p = .0001) for HDL-c, and 1.234 ± 0.097 (p = 0.03) for LDL. Analysis of receiver operating characteristic curves showed that only TG/HDL-c and HDL-c were useful for detecting extensive coronary disease, with the former more strongly associated with disease. CONCLUSIONS: Although some lipid variables were associated with the extent of coronary disease, the ratio of triglycerides to HDL-cholesterol showed the strongest association with extent.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322008000400003LipidsTriglyceridesHDLCholesterolCoronary disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Protasio Lemos da Luz Desiderio Favarato Jose Rocha Faria-Neto Junior Pedro Lemos Antonio Carlos Palandri Chagas |
spellingShingle |
Protasio Lemos da Luz Desiderio Favarato Jose Rocha Faria-Neto Junior Pedro Lemos Antonio Carlos Palandri Chagas High ratio of triglycerides to hdl-cholesterol predicts extensive coronary disease Clinics Lipids Triglycerides HDL Cholesterol Coronary disease |
author_facet |
Protasio Lemos da Luz Desiderio Favarato Jose Rocha Faria-Neto Junior Pedro Lemos Antonio Carlos Palandri Chagas |
author_sort |
Protasio Lemos da Luz |
title |
High ratio of triglycerides to hdl-cholesterol predicts extensive coronary disease |
title_short |
High ratio of triglycerides to hdl-cholesterol predicts extensive coronary disease |
title_full |
High ratio of triglycerides to hdl-cholesterol predicts extensive coronary disease |
title_fullStr |
High ratio of triglycerides to hdl-cholesterol predicts extensive coronary disease |
title_full_unstemmed |
High ratio of triglycerides to hdl-cholesterol predicts extensive coronary disease |
title_sort |
high ratio of triglycerides to hdl-cholesterol predicts extensive coronary disease |
publisher |
Faculdade de Medicina / USP |
series |
Clinics |
issn |
1807-5932 1980-5322 |
publishDate |
2008-01-01 |
description |
An abnormal ratio of triglycerides to HDL-cholesterol (TG/HDL-c) indicates an atherogenic lipid profile and a risk for the development of coronary disease. OBJECTIVE: To investigate the association between lipid levels, specifically TG/HDL-c, and the extent of coronary disease. METHODS: High-risk patients (n = 374) submitted for coronary angiography had their lipid variables measured and coronary disease extent scored by the Friesinger index. RESULTS: The subjects consisted of 220 males and 154 females, age 57.2 ± 11.1 years, with total cholesterol of 210± 50.3 mg/dL, triglycerides of 173.8 ± 169.8 mg/dL, HDL-cholesterol (HDL-c) of 40.1 ± 12.8 mg/dL, LDL-cholesterol (LDL-c) of 137.3 ± 46.2 mg/dL, TG/HDL-c of 5.1 ± 5.3, and a Friesinger index of 6.6 ± 4.7. The relationship between the extent of coronary disease (dichotomized by a Friesenger index of 5 and lipid levels (normal vs. abnormal) was statistically significant for the following: triglycerides, odds ratio of 2.02 (1.31-3.1; p = 0.0018); HDL-c, odds ratio of 2.21 (1.42-3.43; p = 0.0005); and TG/HDL-c, odds ratio of 2.01(1.30-3.09; p = 0.0018). However, the relationship was not significant between extent of coronary disease and total cholesterol [1.25 (0.82-1.91; p = 0.33)] or LDL-c [1.47 (0.96-2.25; p = 0.0842)]. The chi-square for linear trends for Friesinger > 4 and lipid quartiles was statistically significant for triglycerides (p = 0.0017), HDL-c (p = 0.0001), and TG/HDL-c (p = 0.0018), but not for total cholesterol (p = 0.393) or LDL-c (p = 0.0568). The multivariate analysis by logistic regression OR gave 1.3 ± 0.79 (p = .0001) for TG/HDL-c, 0.779 ± 0.074 (p = .0001) for HDL-c, and 1.234 ± 0.097 (p = 0.03) for LDL. Analysis of receiver operating characteristic curves showed that only TG/HDL-c and HDL-c were useful for detecting extensive coronary disease, with the former more strongly associated with disease. CONCLUSIONS: Although some lipid variables were associated with the extent of coronary disease, the ratio of triglycerides to HDL-cholesterol showed the strongest association with extent. |
topic |
Lipids Triglycerides HDL Cholesterol Coronary disease |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322008000400003 |
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