Neurocognitive impairment in patients with bipolar disorder: Comparison between first episode and multiple episodes
Background: Several lines of evidence in the last few years have suggested the critical role of neurocognitive deficits in functional recovery of patients with bipolar disorder (BD). However, whether these deficits are static or progressive with the course of the illness is still debated. Surprising...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2020-01-01
|
Series: | Annals of Indian Psychiatry |
Subjects: | |
Online Access: | http://www.anip.co.in/article.asp?issn=2588-8358;year=2020;volume=4;issue=1;spage=63;epage=69;aulast=Achalia |
id |
doaj-04a6880020dd4848a10d23f362642d29 |
---|---|
record_format |
Article |
spelling |
doaj-04a6880020dd4848a10d23f362642d292020-11-25T03:52:33ZengWolters Kluwer Medknow Publications Annals of Indian Psychiatry2588-83582588-83662020-01-0141636910.4103/aip.aip_73_19Neurocognitive impairment in patients with bipolar disorder: Comparison between first episode and multiple episodesRashmin AchaliaGarimaa AchaliaSudhir ChaudharyMahesh ChopadeVarsha KaginalkarAbhijit SableArpitha JacobGanesan VenkatasubramanianNaren P RaoBackground: Several lines of evidence in the last few years have suggested the critical role of neurocognitive deficits in functional recovery of patients with bipolar disorder (BD). However, whether these deficits are static or progressive with the course of the illness is still debated. Surprisingly, the effect of multiple episodes on neurocognitive deficits in BD is rarely examined in first-episode Indian patients. Hence, in this study, we aimed to examine the difference between first episode mania and BD patients with multiple episodes. Methodology: Thirty patients with the Diagnostic and Statistical Manual of Mental Disorders-IV BD-I (13 with first-episode mania; 17 with multiple episodes) and 30 age- and sex-matched healthy volunteers (HV) were recruited in the study. Clinical severity was assessed using structured rating scales. All patients performed tests to measure executive functions, namely continuous performance test, Stroop color word interference test, and Wisconsin Card Sorting Test. Differences between groups were examined using the analysis of covariance with age and sex as covariates with Bonferroni post hoc analysis. Results: There was a significant difference between groups on the performance of all three tests with patients performing poorer than HV. While the HV differed from both first episode mania and BD with multiple episodes, there was no difference between the two patient subgroups. There was no significant correlation between clinical variables and scores on neurocognitive tests. Conclusions: The study findings, with respect to cognitive function, supports neurodevelopmental than neurodegenerative hypothesis. Findings indicate the need to assess cognitive functions in all patients with BD including first episode BD.http://www.anip.co.in/article.asp?issn=2588-8358;year=2020;volume=4;issue=1;spage=63;epage=69;aulast=Achaliabipolar disorderepisodeexecutive functionsneurodevelopmentneuropsychologyprogression |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rashmin Achalia Garimaa Achalia Sudhir Chaudhary Mahesh Chopade Varsha Kaginalkar Abhijit Sable Arpitha Jacob Ganesan Venkatasubramanian Naren P Rao |
spellingShingle |
Rashmin Achalia Garimaa Achalia Sudhir Chaudhary Mahesh Chopade Varsha Kaginalkar Abhijit Sable Arpitha Jacob Ganesan Venkatasubramanian Naren P Rao Neurocognitive impairment in patients with bipolar disorder: Comparison between first episode and multiple episodes Annals of Indian Psychiatry bipolar disorder episode executive functions neurodevelopment neuropsychology progression |
author_facet |
Rashmin Achalia Garimaa Achalia Sudhir Chaudhary Mahesh Chopade Varsha Kaginalkar Abhijit Sable Arpitha Jacob Ganesan Venkatasubramanian Naren P Rao |
author_sort |
Rashmin Achalia |
title |
Neurocognitive impairment in patients with bipolar disorder: Comparison between first episode and multiple episodes |
title_short |
Neurocognitive impairment in patients with bipolar disorder: Comparison between first episode and multiple episodes |
title_full |
Neurocognitive impairment in patients with bipolar disorder: Comparison between first episode and multiple episodes |
title_fullStr |
Neurocognitive impairment in patients with bipolar disorder: Comparison between first episode and multiple episodes |
title_full_unstemmed |
Neurocognitive impairment in patients with bipolar disorder: Comparison between first episode and multiple episodes |
title_sort |
neurocognitive impairment in patients with bipolar disorder: comparison between first episode and multiple episodes |
publisher |
Wolters Kluwer Medknow Publications |
series |
Annals of Indian Psychiatry |
issn |
2588-8358 2588-8366 |
publishDate |
2020-01-01 |
description |
Background: Several lines of evidence in the last few years have suggested the critical role of neurocognitive deficits in functional recovery of patients with bipolar disorder (BD). However, whether these deficits are static or progressive with the course of the illness is still debated. Surprisingly, the effect of multiple episodes on neurocognitive deficits in BD is rarely examined in first-episode Indian patients. Hence, in this study, we aimed to examine the difference between first episode mania and BD patients with multiple episodes. Methodology: Thirty patients with the Diagnostic and Statistical Manual of Mental Disorders-IV BD-I (13 with first-episode mania; 17 with multiple episodes) and 30 age- and sex-matched healthy volunteers (HV) were recruited in the study. Clinical severity was assessed using structured rating scales. All patients performed tests to measure executive functions, namely continuous performance test, Stroop color word interference test, and Wisconsin Card Sorting Test. Differences between groups were examined using the analysis of covariance with age and sex as covariates with Bonferroni post hoc analysis. Results: There was a significant difference between groups on the performance of all three tests with patients performing poorer than HV. While the HV differed from both first episode mania and BD with multiple episodes, there was no difference between the two patient subgroups. There was no significant correlation between clinical variables and scores on neurocognitive tests. Conclusions: The study findings, with respect to cognitive function, supports neurodevelopmental than neurodegenerative hypothesis. Findings indicate the need to assess cognitive functions in all patients with BD including first episode BD. |
topic |
bipolar disorder episode executive functions neurodevelopment neuropsychology progression |
url |
http://www.anip.co.in/article.asp?issn=2588-8358;year=2020;volume=4;issue=1;spage=63;epage=69;aulast=Achalia |
work_keys_str_mv |
AT rashminachalia neurocognitiveimpairmentinpatientswithbipolardisordercomparisonbetweenfirstepisodeandmultipleepisodes AT garimaaachalia neurocognitiveimpairmentinpatientswithbipolardisordercomparisonbetweenfirstepisodeandmultipleepisodes AT sudhirchaudhary neurocognitiveimpairmentinpatientswithbipolardisordercomparisonbetweenfirstepisodeandmultipleepisodes AT maheshchopade neurocognitiveimpairmentinpatientswithbipolardisordercomparisonbetweenfirstepisodeandmultipleepisodes AT varshakaginalkar neurocognitiveimpairmentinpatientswithbipolardisordercomparisonbetweenfirstepisodeandmultipleepisodes AT abhijitsable neurocognitiveimpairmentinpatientswithbipolardisordercomparisonbetweenfirstepisodeandmultipleepisodes AT arpithajacob neurocognitiveimpairmentinpatientswithbipolardisordercomparisonbetweenfirstepisodeandmultipleepisodes AT ganesanvenkatasubramanian neurocognitiveimpairmentinpatientswithbipolardisordercomparisonbetweenfirstepisodeandmultipleepisodes AT narenprao neurocognitiveimpairmentinpatientswithbipolardisordercomparisonbetweenfirstepisodeandmultipleepisodes |
_version_ |
1724482229550186496 |