Ferroptosis becomes immunogenic: implications for anticancer treatments

Ferroptosis becomes immunogenic: implications for anticancer treatments

Ferroptosis is an iron-dependent form of non-apoptotic cell death that has recently been attributed with antitumor immune effects. Thus, early ferroptotic cells underwent immunogenic cell death that was accompanied by the emission of damage-associated molecular patterns (DAMPs) and triggered dendrit...

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Bibliographic Details
Main Authors: Daolin Tang, Oliver Kepp, Guido Kroemer
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
damage-associated molecular pattern
dendritic cells
anticancer vaccination
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1862949
Description
Summary:Ferroptosis is an iron-dependent form of non-apoptotic cell death that has recently been attributed with antitumor immune effects. Thus, early ferroptotic cells underwent immunogenic cell death that was accompanied by the emission of damage-associated molecular patterns (DAMPs) and triggered dendritic cell maturation in vitro. Furthermore, ferroptotic cells were able to vaccinate against a rechallenge with fibrosarcoma in preclinical models.
ISSN:2162-402X

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