Imaging Fluorophore-Labelled Intestinal Tissue via Fluorescence Endoscope Capsule
The authors have developed a wireless fluorescence imaging capsule endoscope, potentially capable of detecting early signs of disease in the human intestine which can be missed by white-light imaging (WLI) capsule endoscopy (Figure 1). Intestinal fluorescence imaging exploits variations in tissue au...
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doaj-04b068ce444547ba903ccdef58347aef2020-11-24T23:57:19ZengMDPI AGProceedings2504-39002018-11-0121376610.3390/proceedings2130766proceedings2130766Imaging Fluorophore-Labelled Intestinal Tissue via Fluorescence Endoscope CapsuleJames Beeley0Gianluca Melino1Mohammed Al-Rawahani2Mihnea Turcanu3Fraser Stewart4Sandy Cochran5David Cumming6School of Engineering, University of Glasgow, Glasgow, Scotland G12 8LT, UKSchool of Engineering, University of Glasgow, Glasgow, Scotland G12 8LT, UKSchool of Engineering, University of Glasgow, Glasgow, Scotland G12 8LT, UKSchool of Engineering, University of Glasgow, Glasgow, Scotland G12 8LT, UKSchool of Science and Engineering, University of Dundee, Scotland DD1 4HN, UKSchool of Engineering, University of Glasgow, Glasgow, Scotland G12 8LT, UKSchool of Engineering, University of Glasgow, Glasgow, Scotland G12 8LT, UKThe authors have developed a wireless fluorescence imaging capsule endoscope, potentially capable of detecting early signs of disease in the human intestine which can be missed by white-light imaging (WLI) capsule endoscopy (Figure 1). Intestinal fluorescence imaging exploits variations in tissue autofluorescence between healthy and diseased areas in response to illumination, or application of fluorescent labels which preferentially bind to diseased sites. To validate the capsule’s capability to image fluorescently-labelled tissue, a small area of a sample of ex vivo porcine small intestine was sonicated with 6 nm CdZnMg fluorescent quantum dots, and the labelled area clearly differentiated from surrounding tissue by the fluorescence imaging capsule.https://www.mdpi.com/2504-3900/2/13/766capsule endoscopyfluorescence imagingfluorescence labellingtissue fluorescence |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
James Beeley Gianluca Melino Mohammed Al-Rawahani Mihnea Turcanu Fraser Stewart Sandy Cochran David Cumming |
spellingShingle |
James Beeley Gianluca Melino Mohammed Al-Rawahani Mihnea Turcanu Fraser Stewart Sandy Cochran David Cumming Imaging Fluorophore-Labelled Intestinal Tissue via Fluorescence Endoscope Capsule Proceedings capsule endoscopy fluorescence imaging fluorescence labelling tissue fluorescence |
author_facet |
James Beeley Gianluca Melino Mohammed Al-Rawahani Mihnea Turcanu Fraser Stewart Sandy Cochran David Cumming |
author_sort |
James Beeley |
title |
Imaging Fluorophore-Labelled Intestinal Tissue via Fluorescence Endoscope Capsule |
title_short |
Imaging Fluorophore-Labelled Intestinal Tissue via Fluorescence Endoscope Capsule |
title_full |
Imaging Fluorophore-Labelled Intestinal Tissue via Fluorescence Endoscope Capsule |
title_fullStr |
Imaging Fluorophore-Labelled Intestinal Tissue via Fluorescence Endoscope Capsule |
title_full_unstemmed |
Imaging Fluorophore-Labelled Intestinal Tissue via Fluorescence Endoscope Capsule |
title_sort |
imaging fluorophore-labelled intestinal tissue via fluorescence endoscope capsule |
publisher |
MDPI AG |
series |
Proceedings |
issn |
2504-3900 |
publishDate |
2018-11-01 |
description |
The authors have developed a wireless fluorescence imaging capsule endoscope, potentially capable of detecting early signs of disease in the human intestine which can be missed by white-light imaging (WLI) capsule endoscopy (Figure 1). Intestinal fluorescence imaging exploits variations in tissue autofluorescence between healthy and diseased areas in response to illumination, or application of fluorescent labels which preferentially bind to diseased sites. To validate the capsule’s capability to image fluorescently-labelled tissue, a small area of a sample of ex vivo porcine small intestine was sonicated with 6 nm CdZnMg fluorescent quantum dots, and the labelled area clearly differentiated from surrounding tissue by the fluorescence imaging capsule. |
topic |
capsule endoscopy fluorescence imaging fluorescence labelling tissue fluorescence |
url |
https://www.mdpi.com/2504-3900/2/13/766 |
work_keys_str_mv |
AT jamesbeeley imagingfluorophorelabelledintestinaltissueviafluorescenceendoscopecapsule AT gianlucamelino imagingfluorophorelabelledintestinaltissueviafluorescenceendoscopecapsule AT mohammedalrawahani imagingfluorophorelabelledintestinaltissueviafluorescenceendoscopecapsule AT mihneaturcanu imagingfluorophorelabelledintestinaltissueviafluorescenceendoscopecapsule AT fraserstewart imagingfluorophorelabelledintestinaltissueviafluorescenceendoscopecapsule AT sandycochran imagingfluorophorelabelledintestinaltissueviafluorescenceendoscopecapsule AT davidcumming imagingfluorophorelabelledintestinaltissueviafluorescenceendoscopecapsule |
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1725454570574839808 |