Imaging Fluorophore-Labelled Intestinal Tissue via Fluorescence Endoscope Capsule

The authors have developed a wireless fluorescence imaging capsule endoscope, potentially capable of detecting early signs of disease in the human intestine which can be missed by white-light imaging (WLI) capsule endoscopy (Figure 1). Intestinal fluorescence imaging exploits variations in tissue au...

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Main Authors:	James Beeley, Gianluca Melino, Mohammed Al-Rawahani, Mihnea Turcanu, Fraser Stewart, Sandy Cochran, David Cumming
Format:	Article
Language:	English
Published:	MDPI AG 2018-11-01
Series:	Proceedings
Subjects:	capsule endoscopy fluorescence imaging fluorescence labelling tissue fluorescence
Online Access:	https://www.mdpi.com/2504-3900/2/13/766

id	doaj-04b068ce444547ba903ccdef58347aef
record_format	Article
spelling	doaj-04b068ce444547ba903ccdef58347aef2020-11-24T23:57:19ZengMDPI AGProceedings2504-39002018-11-0121376610.3390/proceedings2130766proceedings2130766Imaging Fluorophore-Labelled Intestinal Tissue via Fluorescence Endoscope CapsuleJames Beeley0Gianluca Melino1Mohammed Al-Rawahani2Mihnea Turcanu3Fraser Stewart4Sandy Cochran5David Cumming6School of Engineering, University of Glasgow, Glasgow, Scotland G12 8LT, UKSchool of Engineering, University of Glasgow, Glasgow, Scotland G12 8LT, UKSchool of Engineering, University of Glasgow, Glasgow, Scotland G12 8LT, UKSchool of Engineering, University of Glasgow, Glasgow, Scotland G12 8LT, UKSchool of Science and Engineering, University of Dundee, Scotland DD1 4HN, UKSchool of Engineering, University of Glasgow, Glasgow, Scotland G12 8LT, UKSchool of Engineering, University of Glasgow, Glasgow, Scotland G12 8LT, UKThe authors have developed a wireless fluorescence imaging capsule endoscope, potentially capable of detecting early signs of disease in the human intestine which can be missed by white-light imaging (WLI) capsule endoscopy (Figure 1). Intestinal fluorescence imaging exploits variations in tissue autofluorescence between healthy and diseased areas in response to illumination, or application of fluorescent labels which preferentially bind to diseased sites. To validate the capsule’s capability to image fluorescently-labelled tissue, a small area of a sample of ex vivo porcine small intestine was sonicated with 6 nm CdZnMg fluorescent quantum dots, and the labelled area clearly differentiated from surrounding tissue by the fluorescence imaging capsule.https://www.mdpi.com/2504-3900/2/13/766capsule endoscopyfluorescence imagingfluorescence labellingtissue fluorescence
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	James Beeley Gianluca Melino Mohammed Al-Rawahani Mihnea Turcanu Fraser Stewart Sandy Cochran David Cumming
spellingShingle	James Beeley Gianluca Melino Mohammed Al-Rawahani Mihnea Turcanu Fraser Stewart Sandy Cochran David Cumming Imaging Fluorophore-Labelled Intestinal Tissue via Fluorescence Endoscope Capsule Proceedings capsule endoscopy fluorescence imaging fluorescence labelling tissue fluorescence
author_facet	James Beeley Gianluca Melino Mohammed Al-Rawahani Mihnea Turcanu Fraser Stewart Sandy Cochran David Cumming
author_sort	James Beeley
title	Imaging Fluorophore-Labelled Intestinal Tissue via Fluorescence Endoscope Capsule
title_short	Imaging Fluorophore-Labelled Intestinal Tissue via Fluorescence Endoscope Capsule
title_full	Imaging Fluorophore-Labelled Intestinal Tissue via Fluorescence Endoscope Capsule
title_fullStr	Imaging Fluorophore-Labelled Intestinal Tissue via Fluorescence Endoscope Capsule
title_full_unstemmed	Imaging Fluorophore-Labelled Intestinal Tissue via Fluorescence Endoscope Capsule
title_sort	imaging fluorophore-labelled intestinal tissue via fluorescence endoscope capsule
publisher	MDPI AG
series	Proceedings
issn	2504-3900
publishDate	2018-11-01
description	The authors have developed a wireless fluorescence imaging capsule endoscope, potentially capable of detecting early signs of disease in the human intestine which can be missed by white-light imaging (WLI) capsule endoscopy (Figure 1). Intestinal fluorescence imaging exploits variations in tissue autofluorescence between healthy and diseased areas in response to illumination, or application of fluorescent labels which preferentially bind to diseased sites. To validate the capsule’s capability to image fluorescently-labelled tissue, a small area of a sample of ex vivo porcine small intestine was sonicated with 6 nm CdZnMg fluorescent quantum dots, and the labelled area clearly differentiated from surrounding tissue by the fluorescence imaging capsule.
topic	capsule endoscopy fluorescence imaging fluorescence labelling tissue fluorescence
url	https://www.mdpi.com/2504-3900/2/13/766
work_keys_str_mv	AT jamesbeeley imagingfluorophorelabelledintestinaltissueviafluorescenceendoscopecapsule AT gianlucamelino imagingfluorophorelabelledintestinaltissueviafluorescenceendoscopecapsule AT mohammedalrawahani imagingfluorophorelabelledintestinaltissueviafluorescenceendoscopecapsule AT mihneaturcanu imagingfluorophorelabelledintestinaltissueviafluorescenceendoscopecapsule AT fraserstewart imagingfluorophorelabelledintestinaltissueviafluorescenceendoscopecapsule AT sandycochran imagingfluorophorelabelledintestinaltissueviafluorescenceendoscopecapsule AT davidcumming imagingfluorophorelabelledintestinaltissueviafluorescenceendoscopecapsule
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Imaging Fluorophore-Labelled Intestinal Tissue via Fluorescence Endoscope Capsule

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