Predictive factors of occult neck metastasis in patients with oral squamous cell carcinoma
ABSTRACT INTRODUCTION: It is well established that cervical lymph node metastasis is the most important prognostic factor in patients with oral squamous cell carcinoma of the upper aerodigestive tract. The definition of parameters and classifications that could separate patients in groups of low, i...
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doaj-04b285ec50fa4e53abb0f98ed257056d2021-02-02T06:22:37ZengElsevierBrazilian Journal of Otorhinolaryngology1808-868682554354710.1016/j.bjorl.2015.09.005S1808-86942016000500543Predictive factors of occult neck metastasis in patients with oral squamous cell carcinomaRenato Fortes BittarHomero Penha FerraroMarcelo Haddad RibasCarlos Neutzling LehnABSTRACT INTRODUCTION: It is well established that cervical lymph node metastasis is the most important prognostic factor in patients with oral squamous cell carcinoma of the upper aerodigestive tract. The definition of parameters and classifications that could separate patients in groups of low, intermediate and high-risk is being attempted for several years. OBJECTIVE: The objective of this study was to determine possible predictive factors related to the occurrence of occult cervical lymph node metastasis through the analysis of histopathological reports of surgical specimens obtained after oral squamous cell carcinoma resection and selective neck dissections of patients initially classified as N0. METHODS: This was a primary, retrospective, observational, case-control study. Histopathological reports were reviewed to determine if some findings were related to the occurrence of occult lymph node metastasis. The events analyzed were oral cavity subsites, pT-stage, muscular infiltration, desmoplasia, vascular emboli, perineural infiltration, tumor thickness and compromised margins. RESULTS: Occult cervical metastasis accounted for 19.10 percent of the cases. Desmoplasia, perineural infiltration, tumor thickness and pT4a stage are predictive factors of occult neck metastasis (p-value = 0.0488, 0.0326, 0.0395, 0.0488, respectively). CONCLUSION: The accurate definition of predictive factors of occult cervical metastasis may guide the selection of patients that should be referred to radiotherapy, avoiding the unnecessary exposure of low-risk patients to radiation and allowing a better regional control of the disease in those of moderate or high risk.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942016000500543&lng=en&tlng=enHead and neck neoplasmsOral neoplasmsSurvival outcomesLymph node metastasisPrognosisSquamous cell carcinoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Renato Fortes Bittar Homero Penha Ferraro Marcelo Haddad Ribas Carlos Neutzling Lehn |
spellingShingle |
Renato Fortes Bittar Homero Penha Ferraro Marcelo Haddad Ribas Carlos Neutzling Lehn Predictive factors of occult neck metastasis in patients with oral squamous cell carcinoma Brazilian Journal of Otorhinolaryngology Head and neck neoplasms Oral neoplasms Survival outcomes Lymph node metastasis Prognosis Squamous cell carcinoma |
author_facet |
Renato Fortes Bittar Homero Penha Ferraro Marcelo Haddad Ribas Carlos Neutzling Lehn |
author_sort |
Renato Fortes Bittar |
title |
Predictive factors of occult neck metastasis in patients with oral squamous cell carcinoma |
title_short |
Predictive factors of occult neck metastasis in patients with oral squamous cell carcinoma |
title_full |
Predictive factors of occult neck metastasis in patients with oral squamous cell carcinoma |
title_fullStr |
Predictive factors of occult neck metastasis in patients with oral squamous cell carcinoma |
title_full_unstemmed |
Predictive factors of occult neck metastasis in patients with oral squamous cell carcinoma |
title_sort |
predictive factors of occult neck metastasis in patients with oral squamous cell carcinoma |
publisher |
Elsevier |
series |
Brazilian Journal of Otorhinolaryngology |
issn |
1808-8686 |
description |
ABSTRACT INTRODUCTION: It is well established that cervical lymph node metastasis is the most important prognostic factor in patients with oral squamous cell carcinoma of the upper aerodigestive tract. The definition of parameters and classifications that could separate patients in groups of low, intermediate and high-risk is being attempted for several years. OBJECTIVE: The objective of this study was to determine possible predictive factors related to the occurrence of occult cervical lymph node metastasis through the analysis of histopathological reports of surgical specimens obtained after oral squamous cell carcinoma resection and selective neck dissections of patients initially classified as N0. METHODS: This was a primary, retrospective, observational, case-control study. Histopathological reports were reviewed to determine if some findings were related to the occurrence of occult lymph node metastasis. The events analyzed were oral cavity subsites, pT-stage, muscular infiltration, desmoplasia, vascular emboli, perineural infiltration, tumor thickness and compromised margins. RESULTS: Occult cervical metastasis accounted for 19.10 percent of the cases. Desmoplasia, perineural infiltration, tumor thickness and pT4a stage are predictive factors of occult neck metastasis (p-value = 0.0488, 0.0326, 0.0395, 0.0488, respectively). CONCLUSION: The accurate definition of predictive factors of occult cervical metastasis may guide the selection of patients that should be referred to radiotherapy, avoiding the unnecessary exposure of low-risk patients to radiation and allowing a better regional control of the disease in those of moderate or high risk. |
topic |
Head and neck neoplasms Oral neoplasms Survival outcomes Lymph node metastasis Prognosis Squamous cell carcinoma |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942016000500543&lng=en&tlng=en |
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