In vitro and in vivo degradation behavior of Mg–2Sr–Ca and Mg–2Sr–Zn alloys

In vitro and in vivo degradation behavior of Mg–2Sr–Ca and Mg–2Sr–Zn alloys

Magnesium alloys with integration of degradability and good mechanical performance are desired for orthopedic implants. In this paper, Mg–2Sr–Ca and Mg–2Sr–Zn alloys were prepared and the degradation as well as the bone response were investigated. Compared with the binary Mg–2Sr alloys, the addition...

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Main Authors: Kai Chen, Xinhui Xie, Hongyan Tang, Hui Sun, Ling Qin, Yufeng Zheng, Xuenan Gu, Yubo Fan
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2020-06-01
Series:Bioactive Materials
Subjects:
Magnesium alloys
Degradation
In vivo test
Biocompatibility
Orthopedic implants
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X20300372
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spelling doaj-04c422f21bf84716a1da07af5ee78acd2021-04-02T14:15:25ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2020-06-0152275285In vitro and in vivo degradation behavior of Mg–2Sr–Ca and Mg–2Sr–Zn alloysKai Chen0Xinhui Xie1Hongyan Tang2Hui Sun3Ling Qin4Yufeng Zheng5Xuenan Gu6Yubo Fan7Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China; Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, 100083, ChinaThe Department of Orthopedics, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, 210009, China; Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong National Research Center for Rehabilitation Technical Aids, Beijing, 100176, ChinaKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China; Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, 100083, ChinaKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China; Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, 100083, ChinaDepartment of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong National Research Center for Rehabilitation Technical Aids, Beijing, 100176, ChinaDepartment of Materials Science and Engineering, College of Engineering, Peking University, Beijing, 100871, ChinaKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China; Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, 100083, China; Corresponding author. School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China; Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, 100083, China; National Research Center for Rehabilitation Technical Aids, Beijing, 100176, China; Corresponding author. School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.Magnesium alloys with integration of degradability and good mechanical performance are desired for orthopedic implants. In this paper, Mg–2Sr–Ca and Mg–2Sr–Zn alloys were prepared and the degradation as well as the bone response were investigated. Compared with the binary Mg–2Sr alloys, the addition of Ca and Zn improved the in vitro and in vivo corrosion resistance. Mg–2Sr–Ca and Mg–2Sr–Zn alloys exhibited more uniform corrosion and maintained the configuration of the implants 4 weeks post-implantation. The in vivo corrosion rates were 0.85 mm/yr for Mg–2Sr–Zn and 1.10 mm/yr for Mg–2Sr–Ca in comparison with 1.37 mm/yr for Mg–2Sr. The in vitro cell tests indicated that Mg–2Sr–Ca and Mg–2Sr–Zn alloys exhibited higher MG63 cell viability than Mg–2Sr alloy. Furthermore, these two alloys can promote the mineralization and new bone formation without inducing any significant adverse effects and this sound osteogenic properties suggest its attractive clinical potential.http://www.sciencedirect.com/science/article/pii/S2452199X20300372Magnesium alloysDegradationIn vivo testBiocompatibilityOrthopedic implants
collection DOAJ
language English
format Article
sources DOAJ
author Kai Chen
Xinhui Xie
Hongyan Tang
Hui Sun
Ling Qin
Yufeng Zheng
Xuenan Gu
Yubo Fan
spellingShingle Kai Chen
Xinhui Xie
Hongyan Tang
Hui Sun
Ling Qin
Yufeng Zheng
Xuenan Gu
Yubo Fan
In vitro and in vivo degradation behavior of Mg–2Sr–Ca and Mg–2Sr–Zn alloys
Bioactive Materials
Magnesium alloys
Degradation
In vivo test
Biocompatibility
Orthopedic implants
author_facet Kai Chen
Xinhui Xie
Hongyan Tang
Hui Sun
Ling Qin
Yufeng Zheng
Xuenan Gu
Yubo Fan
author_sort Kai Chen
title In vitro and in vivo degradation behavior of Mg–2Sr–Ca and Mg–2Sr–Zn alloys
title_short In vitro and in vivo degradation behavior of Mg–2Sr–Ca and Mg–2Sr–Zn alloys
title_full In vitro and in vivo degradation behavior of Mg–2Sr–Ca and Mg–2Sr–Zn alloys
title_fullStr In vitro and in vivo degradation behavior of Mg–2Sr–Ca and Mg–2Sr–Zn alloys
title_full_unstemmed In vitro and in vivo degradation behavior of Mg–2Sr–Ca and Mg–2Sr–Zn alloys
title_sort in vitro and in vivo degradation behavior of mg–2sr–ca and mg–2sr–zn alloys
publisher KeAi Communications Co., Ltd.
series Bioactive Materials
issn 2452-199X
publishDate 2020-06-01
description Magnesium alloys with integration of degradability and good mechanical performance are desired for orthopedic implants. In this paper, Mg–2Sr–Ca and Mg–2Sr–Zn alloys were prepared and the degradation as well as the bone response were investigated. Compared with the binary Mg–2Sr alloys, the addition of Ca and Zn improved the in vitro and in vivo corrosion resistance. Mg–2Sr–Ca and Mg–2Sr–Zn alloys exhibited more uniform corrosion and maintained the configuration of the implants 4 weeks post-implantation. The in vivo corrosion rates were 0.85 mm/yr for Mg–2Sr–Zn and 1.10 mm/yr for Mg–2Sr–Ca in comparison with 1.37 mm/yr for Mg–2Sr. The in vitro cell tests indicated that Mg–2Sr–Ca and Mg–2Sr–Zn alloys exhibited higher MG63 cell viability than Mg–2Sr alloy. Furthermore, these two alloys can promote the mineralization and new bone formation without inducing any significant adverse effects and this sound osteogenic properties suggest its attractive clinical potential.
topic Magnesium alloys
Degradation
In vivo test
Biocompatibility
Orthopedic implants
url http://www.sciencedirect.com/science/article/pii/S2452199X20300372
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