Correlation between the High Density Lipoprotein and its Subtypes in Coronary Heart Disease

• Main Authors: Fen Gao, Ya-juan Ren, Xiao-yu Shen, Yun-fei Bian, Chuan-shi Xiao, Hong Li
• Format: Article
• Language: English
• Published: Cell Physiol Biochem Press GmbH & Co KG 2016-05-01
• Series: Cellular Physiology and Biochemistry
• Subjects: HDL subtypes; Correlation; CHD
• Online Access: http://www.karger.com/Article/FullText/445552

Background/Aims: To detect the changes of high density lipoprotein (HDL) and its subtypes in serum of patients with coronary heart disease (CHD). Methods: 337 hospitalized patients were selected from our hospital during August, 2014 - January, 2015, and divided into CHD group (n = 190) and control group (n = 127). Lipoprint lipoprotein analyzer was used to classify low density lipoprotein (LDL) particle size and its sub-components, as well as HDL particle size and its sub-components. The changes of the subtypes in patients with CHD were statistically analyzed. The possible mechanism was explored. Results: (1) Compared with the control group, the concentration of HDL in CHD patients reduced, HDLL significantly decreased (P S increased (P L had the most significant decreased; (3) HDL and all HDL subtypes were positively correlated with apolipoprotein A-I (apoA-I), of which, HDLL had the biggest correlation with apoA-I (P M had a maximum correlation with HDL (P Conclusion: HDL maturation disorders existed in the serum of CHD patients, HDLL may be protected factor for CHD, whose decrease was closely related wit the risk increase of CHD. The cardiovascular protection function of HDLL may be related with apoA-I content.