Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239

Parasites can increase infection rates andpathogenicity in immunocompromised humanimmunodeficiency virus (HIV) patients. However, invitro studies and epidemiological investigationsalso suggest that parasites might escapeimmunocompromised hosts during HIV infection.Due to the lack of direct evidence...

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Main Authors: Tian-Zhang Song, Ming-Xu Zhang, Yu-Jie Xia, Yu Xiao, Wei Pang, Yong-Tang Zheng
Format: Article
Language:English
Published: Science Press, PR China 2018-01-01
Series:Zoological Research
Subjects:
Online Access:http://www.zoores.ac.cn/EN/abstract/abstract3862.shtml
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spelling doaj-04cbd1614c3448c797c556bfd057f0262020-11-25T00:16:25ZengScience Press, PR ChinaZoological Research2095-81372095-81372018-01-01391425110.24272/j.issn.2095-8137.2018.015Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239Tian-Zhang Song0Ming-Xu Zhang1Yu-Jie Xia2Yu-Jie Xia3Yu Xiao4Wei Pang5Yong-Tang Zheng6Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaKunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, ChinaKunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, ChinaKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of BioactiveKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of BioactiveKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China; Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, ChinaParasites can increase infection rates andpathogenicity in immunocompromised humanimmunodeficiency virus (HIV) patients. However, invitro studies and epidemiological investigationsalso suggest that parasites might escapeimmunocompromised hosts during HIV infection.Due to the lack of direct evidence from animalexperiments, the effects of parasitic infections onimmunocompromised hosts remain unclear. Here,we detected 14 different parasites in six northernpig-tailed macaques (NPMs) before or during the50th week of post-simian immunodeficiency virus(SIV) infection by ELISA. The NPMs all carriedparasites before viral injection. At the 50th week afterviral injection, the individuals with negative resultsin parasitic detection (i.e., 08247 and 08287) werecharacterized as the Parasites Exit (PE) group, withthe other individuals (i.e., 09203, 09211, 10205, and10225) characterized as the Parasites Remain (PR)group. Compared with the PR group, the NPMs in thePE group showed higher viral loads, lower CD4+ Tcells counts, and lower CD4/CD8 rates. Additionally,the PE group had higher immune activation andimmune exhaustion of both CD4+ and CD8+ T cells.Pathological observation showed greater injury tothe liver, cecum, colon, spleen, and mesentericlymph nodes in the PE group. This study showedmore seriously compromised immunity in the PEgroup, strongly indicating that parasites might exit animmunocompromised host.http://www.zoores.ac.cn/EN/abstract/abstract3862.shtmlAIDSImmunocompromisedNorthern pig-tailed macaqueParasite
collection DOAJ
language English
format Article
sources DOAJ
author Tian-Zhang Song
Ming-Xu Zhang
Yu-Jie Xia
Yu-Jie Xia
Yu Xiao
Wei Pang
Yong-Tang Zheng
spellingShingle Tian-Zhang Song
Ming-Xu Zhang
Yu-Jie Xia
Yu-Jie Xia
Yu Xiao
Wei Pang
Yong-Tang Zheng
Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239
Zoological Research
AIDS
Immunocompromised
Northern pig-tailed macaque
Parasite
author_facet Tian-Zhang Song
Ming-Xu Zhang
Yu-Jie Xia
Yu-Jie Xia
Yu Xiao
Wei Pang
Yong-Tang Zheng
author_sort Tian-Zhang Song
title Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239
title_short Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239
title_full Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239
title_fullStr Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239
title_full_unstemmed Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239
title_sort parasites may exit immunocompromised northern pig-tailed macaques (macaca leonina) infected with sivmac239
publisher Science Press, PR China
series Zoological Research
issn 2095-8137
2095-8137
publishDate 2018-01-01
description Parasites can increase infection rates andpathogenicity in immunocompromised humanimmunodeficiency virus (HIV) patients. However, invitro studies and epidemiological investigationsalso suggest that parasites might escapeimmunocompromised hosts during HIV infection.Due to the lack of direct evidence from animalexperiments, the effects of parasitic infections onimmunocompromised hosts remain unclear. Here,we detected 14 different parasites in six northernpig-tailed macaques (NPMs) before or during the50th week of post-simian immunodeficiency virus(SIV) infection by ELISA. The NPMs all carriedparasites before viral injection. At the 50th week afterviral injection, the individuals with negative resultsin parasitic detection (i.e., 08247 and 08287) werecharacterized as the Parasites Exit (PE) group, withthe other individuals (i.e., 09203, 09211, 10205, and10225) characterized as the Parasites Remain (PR)group. Compared with the PR group, the NPMs in thePE group showed higher viral loads, lower CD4+ Tcells counts, and lower CD4/CD8 rates. Additionally,the PE group had higher immune activation andimmune exhaustion of both CD4+ and CD8+ T cells.Pathological observation showed greater injury tothe liver, cecum, colon, spleen, and mesentericlymph nodes in the PE group. This study showedmore seriously compromised immunity in the PEgroup, strongly indicating that parasites might exit animmunocompromised host.
topic AIDS
Immunocompromised
Northern pig-tailed macaque
Parasite
url http://www.zoores.ac.cn/EN/abstract/abstract3862.shtml
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