Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239
Parasites can increase infection rates andpathogenicity in immunocompromised humanimmunodeficiency virus (HIV) patients. However, invitro studies and epidemiological investigationsalso suggest that parasites might escapeimmunocompromised hosts during HIV infection.Due to the lack of direct evidence...
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doaj-04cbd1614c3448c797c556bfd057f0262020-11-25T00:16:25ZengScience Press, PR ChinaZoological Research2095-81372095-81372018-01-01391425110.24272/j.issn.2095-8137.2018.015Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239Tian-Zhang Song0Ming-Xu Zhang1Yu-Jie Xia2Yu-Jie Xia3Yu Xiao4Wei Pang5Yong-Tang Zheng6Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaKunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, ChinaKunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, ChinaKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of BioactiveKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of BioactiveKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China; Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, ChinaParasites can increase infection rates andpathogenicity in immunocompromised humanimmunodeficiency virus (HIV) patients. However, invitro studies and epidemiological investigationsalso suggest that parasites might escapeimmunocompromised hosts during HIV infection.Due to the lack of direct evidence from animalexperiments, the effects of parasitic infections onimmunocompromised hosts remain unclear. Here,we detected 14 different parasites in six northernpig-tailed macaques (NPMs) before or during the50th week of post-simian immunodeficiency virus(SIV) infection by ELISA. The NPMs all carriedparasites before viral injection. At the 50th week afterviral injection, the individuals with negative resultsin parasitic detection (i.e., 08247 and 08287) werecharacterized as the Parasites Exit (PE) group, withthe other individuals (i.e., 09203, 09211, 10205, and10225) characterized as the Parasites Remain (PR)group. Compared with the PR group, the NPMs in thePE group showed higher viral loads, lower CD4+ Tcells counts, and lower CD4/CD8 rates. Additionally,the PE group had higher immune activation andimmune exhaustion of both CD4+ and CD8+ T cells.Pathological observation showed greater injury tothe liver, cecum, colon, spleen, and mesentericlymph nodes in the PE group. This study showedmore seriously compromised immunity in the PEgroup, strongly indicating that parasites might exit animmunocompromised host.http://www.zoores.ac.cn/EN/abstract/abstract3862.shtmlAIDSImmunocompromisedNorthern pig-tailed macaqueParasite |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tian-Zhang Song Ming-Xu Zhang Yu-Jie Xia Yu-Jie Xia Yu Xiao Wei Pang Yong-Tang Zheng |
spellingShingle |
Tian-Zhang Song Ming-Xu Zhang Yu-Jie Xia Yu-Jie Xia Yu Xiao Wei Pang Yong-Tang Zheng Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239 Zoological Research AIDS Immunocompromised Northern pig-tailed macaque Parasite |
author_facet |
Tian-Zhang Song Ming-Xu Zhang Yu-Jie Xia Yu-Jie Xia Yu Xiao Wei Pang Yong-Tang Zheng |
author_sort |
Tian-Zhang Song |
title |
Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239 |
title_short |
Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239 |
title_full |
Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239 |
title_fullStr |
Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239 |
title_full_unstemmed |
Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239 |
title_sort |
parasites may exit immunocompromised northern pig-tailed macaques (macaca leonina) infected with sivmac239 |
publisher |
Science Press, PR China |
series |
Zoological Research |
issn |
2095-8137 2095-8137 |
publishDate |
2018-01-01 |
description |
Parasites can increase infection rates andpathogenicity in immunocompromised humanimmunodeficiency virus (HIV) patients. However, invitro studies and epidemiological investigationsalso suggest that parasites might escapeimmunocompromised hosts during HIV infection.Due to the lack of direct evidence from animalexperiments, the effects of parasitic infections onimmunocompromised hosts remain unclear. Here,we detected 14 different parasites in six northernpig-tailed macaques (NPMs) before or during the50th week of post-simian immunodeficiency virus(SIV) infection by ELISA. The NPMs all carriedparasites before viral injection. At the 50th week afterviral injection, the individuals with negative resultsin parasitic detection (i.e., 08247 and 08287) werecharacterized as the Parasites Exit (PE) group, withthe other individuals (i.e., 09203, 09211, 10205, and10225) characterized as the Parasites Remain (PR)group. Compared with the PR group, the NPMs in thePE group showed higher viral loads, lower CD4+ Tcells counts, and lower CD4/CD8 rates. Additionally,the PE group had higher immune activation andimmune exhaustion of both CD4+ and CD8+ T cells.Pathological observation showed greater injury tothe liver, cecum, colon, spleen, and mesentericlymph nodes in the PE group. This study showedmore seriously compromised immunity in the PEgroup, strongly indicating that parasites might exit animmunocompromised host. |
topic |
AIDS Immunocompromised Northern pig-tailed macaque Parasite |
url |
http://www.zoores.ac.cn/EN/abstract/abstract3862.shtml |
work_keys_str_mv |
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1725382769134010368 |