Characterization of Magnitude and Antigen Specificity of HLA-DP, DQ, and DRB3/4/5 Restricted DENV-Specific CD4+ T Cell Responses

Characterization of Magnitude and Antigen Specificity of HLA-DP, DQ, and DRB3/4/5 Restricted DENV-Specific CD4+ T Cell Responses

Background: Dengue Virus (DENV) associated disease is a major public health problem. Assessment of HLA class II restricted DENV-specific responses is relevant for immunopathology and definition of correlates of protection. While previous studies characterized responses restricted by the HLA-DRB1 loc...

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Bibliographic Details
Main Authors: Alba Grifoni, Eugene Moore, Hannah Voic, John Sidney, Elizabeth Phillips, Ramesh Jadi, Simon Mallal, Aruna D. De Silva, Aravinda M. De Silva, Bjoern Peters, Daniela Weiskopf, Alessandro Sette
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
DENV
CD4+T cells
HLA-DP
HLA-DQ
HLA-DRB3/4/5
adaptive immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01568/full

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